Alteration of Serum Albumin Globulin Ratio in Patients with Lung Cancer
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 2
Abstract
Introduction: Recent studies have demonstrated that hypoalbuminemia and low albumin globulin ratio are important predictors of long term mortality in several cancers. To the best of our knowledge, studies on albumin globulin ratio in lung cancer patients has not been carried out in our population. Aim: To study the alteration in serum albumin, globulin and albumin globulin ratio in patients with histologically diagnosed lung cancer. Materials and methods: This was a retrospective analysis conducted in the department of pulmonary medicine in a tertiary care centre in Kerala. The case records of 21 patients histologically diagnosed as lung cancer were analysed. Blood samples were collected for testing of total protein and albumin before starting treatment. Patients with comorbidities that could alter albumin globulin ratio such as chronic liver disease, renal disease and other chronic inflammatory diseases were excluded from the study. Albumin-globulin ratio (AGR) was calculated using the equation AGR=Albumin (Total protein-albumin). Results: The total number of patients included in the study was 21. The most common histopathological type of lung cancer observed in the study was adenocarcinoma (14/21). Other types were squamous cell (3), small cell (1), carcinoid tumor (1) and poorly differentiated cancer (2). Albumin globulin ratio was < 1 in 14 patients. In another 3 patients the ratio was 1.03. Serum globulin was elevated (>3.5) in nine patients. Serum albumin was low (<3.5) in fourteen patients. Total protein was increased above normal (>7) in two patients in whom globulin was very high (>5). Conclusion: Cancer related inflammation has been a subject of interest in the field of cancer research. This study supports the recently changed concept that cancer cells are capable of producing immunoglobulins as against the older concept that immunoglobulins are produced by B cells alone.
Authors and Affiliations
Mithun Harold T Thomas
Keywords
Related Articles
- EP ID EP506320
- DOI -
- Views 47
- Downloads 0
Case Report of Breast Gangrene
Breast gangrene is a rare but possible complication of inadequate breast abscess drainage in a lactating mother. Associated with very devastating physical and psychological consequences. Fulminating infection of the brea...
Glandular Odontogenic Cyst withan Odontome: An Unusual Association
Glandular odontogenic cyst (GOC)is a relatively rare jaw cyst with frequency of only 0.2%. It is common in 5th -6th decade of life with mean age of occurrence of 45.7 years. It has slight male predominance (M: F; 1.3:1)...
Prospective Randomised Clinical Trial Study of Diclofenac Sodium 100mg Suppository and Trans Dermal Patch for the Duration of post Operative Analgesia in LSCS Patients Under Going Surgery under Lumbar Subarachnoid Block
Background: Post operative analgesia in continuation of lumbar subarachnoid blockade can be effected by several means. But use of non steroid anti inflammatory drugs in various forms is advantageous to the parturient and...
Cancer related fatigue-Analysing its causes to find the road map to its treatment- in the Indian scenario
Introduction: Cancer-related fatigue profoundly affects the physical, psychosocial, and occupational aspects of both patients and their families, thereby it results in marked deterioration of the patient’s quality of lif...
A Study of Severity and Frequency of Anemia in Different Age Group in 6 Months to 5 years Children at a Teaching Hospital in Rural Haryana, India
Background: Anemia is a global health problem in children specially in under five children causing morbidity and mortality. Our aim of this study was to find the prevalence of anemia in different age group and its patter...