Alterations in the invasive properties of peripheral blood monocytes from patients with endometriosis
Journal Title: Clinical and Experimental Obstetrics & Gynecology - Year 2019, Vol 46, Issue 1
Abstract
Purpose of this Investigation: The primary aim of this pilot study was to determine if the increase in monocyte/macrophage number in the peritoneal cavity of women with endometriosis is due to differences in peritoneal fluid signaling content (e.g. cytokine levels) or inherent differences in monocyte migration in response to those signals. Materials and Methods: Peripheral blood and peritoneal fluid samples were collected from endometriosis and surgical control patients at the time of surgery. Peripheral blood was also collected from a group of healthy ‘non-surgical control’ patients in an internal medicine clinic. Monocytes were isolated from blood and invasion was assessed using peritoneal fluid from endometriosis patients and controls as a chemoattractant. Results: Regardless of peritoneal fluid source a > 10-fold change was seen in monocyte invasion with endometriotic monocytes. Conclusion: Peripheral blood monocytes from women with endometriosis are more invasive than those from other women. This is true when compared to both surgical and nonsurgical controls.
Authors and Affiliations
C. E. Bedient, D. Rodriguez, N. Sidell, C. Roberts, S. C. Schutte
Keywords
Related Articles
- EP ID EP618505
- DOI 10.12891/ceog4333.2019
- Views 48
- Downloads 0
Vaginal microbiota composition as a diagnostic tool for bacterial vaginosis in pregnant Korean women
Objectives: To analyze the relative abundance of five Lactobacillus species, Gardnerella vaginalis, and Atopobium vaginae in the vaginal microbiota of pregnant Korean women to establish diagnostic criteria for bacterial...
Preimplantation genetic diagnosis for a single gene mutation for succinate dehydrogenase subunit B (the genetic basis for malignant paraganglioma) with successful pregnancy
Purpose: To report the first successful case of the birth of normal baby using preimplantation diagnosis for hereditary paraganglioma (PGL) followed by embryo transfer and to emphasize the importance of using mild follic...
Laparoscopy decision for precocious pseudopuberty of ovarian origin
Development of autonomous functional ovarian follicular cysts results in precocious pseudopuberty. Conservative approach is the first choice for these patients, and the authors present two cases of precocious pseudopuber...
Weekly vaginal administration of tamoxifen for three months in postmenopausal women with vulvar and vaginal atrophy: a possible new treatment approach?
An exploratory study was conducted recruiting four healthy postmenopausal women suffering from vulvar and vaginal atrophy (VVA). Subjects self-administered vaginal suppositories containing tamoxifen (20 mg). Subjects wer...
Adjusting progesterone (P) dosage to compensate for a non-homogeneous hyperechogenic (HH) echo pattern three days after embryo transfer
Purpose: To determine if in the modern era failing to attain a homogenous hyperechogenic (HH) pattern three days after embryo transfer is still associated with a lower pregnancy rates. The study evaluates the efficacy of...