Altered intrinsic functional connectivity of the primary visual cortex in youth patients with comitant exotropia: a resting state fMRI study
Journal Title: International Journal of Ophthalmology - Year 2018, Vol 11, Issue 4
Abstract
"AIM: To evaluate the differences in the functional connectivity (FC) of the primary visual cortex (V1) between the youth comitant exotropia (CE) patients and health subjects using resting functional magnetic resonance imaging (fMRI) data. METHODS: Totally, 32 CEs (25 males and 7 females) and 32 healthy control subjects (HCs) (25 males and 7 females) were enrolled in the study and underwent the MRI scanning. Two-sample t-test was used to examine differences in FC maps between the CE patients and HCs. RESULTS: The CE patients showed significantly less FC between the left brodmann area (BA17) and left lingual gyrus/cerebellum posterior lobe, right middle occipital gyrus, left precentral gyrus/postcentral gyrus and right inferior parietal lobule/postcentral gyrus. Meanwhile, CE patients showed significantly less FC between right BA17 and right middle occipital gyrus (BA19, 37). CONCLUSION: Our findings show that CE involves abnormal FC in primary visual cortex in many regions, which may underlie the pathologic mechanism of impaired fusion and stereoscopic vision in CEs."
Authors and Affiliations
Yi Shao, Fu-Qing Zhou
Keywords
Related Articles
- EP ID EP491348
- DOI 10.18240/ijo.2018.04.22
- Views 36
- Downloads 0
The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice
"AIM: To investigate the retinal toxicity and pharmacokinetics of simvastatin intravitreally injected into mice. METHODS: Forty-eight 6-8-week-old C57BL/6J mice were used in this study. Simvastatin was intravitreally inj...
Ocular hypertension in patients with central/hemicentral retinal vein occlusions: cumulative prevalence and management
"AIM: To prospectively evaluate the cumulative prevalence and the management of ocular hypertension (OH) in patients with unilateral acute central/hemicentral retinal vein occlusions (C/HCRVOs) over the course of 3y. MET...
A case of non-Acanthamoeba keratitis with radial keratoneuritis
Letter to the Editor
Combined therapy versus anti-vascular endothelial growth factor monotherapy for polypoidal choroidal vasculopathy: a Meta-analysis
"AIM: To evaluate the efficacy and safety of anti-vascular endothelial growth factor (VEGF) combined with photodynamic therapy (PDT) versus anti-VEGF monotherapy for polypoidal choroidal vasculopathy (PCV). METHODS: We c...
Down regulation of UCP2 expression in retinal pigment epithelium cells under oxidative stress: an in vitro study
"AIM: To evaluate the expression of uncoupling protein 2 (UCP2) in a retinal pigment epithelium cell line (ARPE-19), under oxidative stress (OS). METHODS: ARPE-19 cells were divided into groups treated with various conce...