Altered Levels of Serum Adenosine Deaminase in Type 2 Diabetes Mellitus
Journal Title: National Journal of Laboratory Medicine - Year 2019, Vol 8, Issue 2
Abstract
ABSTRACT Introduction: Diabetes Mellitus (DM) is one of the leading not causes of increased morbidity and mortality in developing countries. Adenosine Deaminase (ADA) enzyme in purine metabolism catalyses the irreversible deamination of adenosine to inosine. Literature suggests that adenosine mimics the action of insulin and ADA reduces the adenosine levels, thus alters the intracellular glucose uptake. However, the role of ADA in Type 2 Diabetes Mellitus (T2DM) remains inconclusive. Aim: To measure serum ADA levels in T2DM patients and analyse its correlation with the glycaemic status. Materials and Methods: The case-control study included 54 clinically diagnosed T2DM subjects (aged 30-70 years) on oral hypoglycaemic treatment and 50 sex and age-matched apparently healthy individuals as controls. Serum Adenosine Deaminase (ADA), Fasting Blood Glucose (FBG), HbA1c, Lipid profile, {Total Cholesterol (TC), Triglyceride (TG), High Density Lipoprotein (HDL)} along with anthropometric indices for BMI were measured. Descriptive statistical analysis was done using unpaired Students’ t-test. Pearson correlation was used to analyse the correlation among various parameters. The p-value <0.05 was considered to be statistically significant. Results: In our study, FBG, HbA1c, ADA, TC, TG were significantly increased in T2DM subjects as compared to control group (p-value <0.0001), Triglyceride (p-value <0.001). In contrast, HDL-C levels were significantly reduced (p-value <0.0001) in T2DM subjects compared to control group. BMI of the T2DM subjects was significantly higher (p-value <0.01) than control. A positive correlation between ADA and HbA1c (r -value 0.64: p-value<0.0001), and ADA and FBS (r value 0.48: p-value <0.001) was observed. However, no correlation was found between ADA and BMI (r value 0.01: p-value 0.09). Conclusion: From the current study we propose that serum ADA can be used as a biomarker for predicting the glycaemic status of T2DM patient. It can also be used for assessment of dyslipidemia associated with diabetes.
Authors and Affiliations
P Vijayalakshmi, Supriya .
Keywords
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- EP ID EP610034
- DOI 10.7860/NJLM/2019/41245:2353
- Views 123
- Downloads 0
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