ALTERNATIVES FOR FORCED VITAL CAPACITY (FVC) AND FEV1% DURING PREGNANCY: PRELIMINARY STUDY IN WESTERN GUJARAT
Journal Title: International Journal of Basic and Applied Physiology - Year 2018, Vol 7, Issue 1
Abstract
Background & Objectives: Asian countries need to set their own standards and reference values for spirometry. ATS considered FEV1% as gold standards and recommend 70% of FEV1% as the cut-off. Poor subjective efforts, frustration, time taken and complications as syncope associated with forced spirometry inspires researchers to find out the surrogate of FVC and FEV1%. Present study was aimed to study the forced spirometry during three trimesters of pregnancy with non-pregnant as control group to compare the values of FVC and FEV1% with FEV6 and FEV1/FEV6 in three trimesters of pregnancy and non-pregnant females. Methods: Total 400 participants (100 in each trimester and 100 non pregnant control) attending antenatal clinic of Obstetrics and Gynaecology Department. Dhiraj General Hospital, SVDU were studied for FVC, FEV1, FEV6, FEV1% and FEV1/FEV6 using Digital spirometer (SpiroWin+). ANOVA, Student’s t-test and Mann Whitney test were used for statistical analysis. Results: The values of FVC and FEV6 in all three trimesters of pregnancy were within physiological limit and insignificantly different. Difference for FVC (1.910±0.35 vs 1.952±0.44) and FEV6 (1.619±0.40 vs 1.567±0.34) were observed to be insignificant (p>0.05) when compared for pregnant and non-pregnant groups. FEV1% and FEV1/FEV6 for all the groups were comparable and well above the 70%. Mann Whitney test for comparison of FVC with FEV6 and FEV1/FVC with FEV1/FEV6 insignificant variations within the trimesters.Conclusion: FEV6 can be effectively used in place of FVC in evaluation of lung function test, since the values are highly correlative at all the levels. Compared with measurements of FVC, using FEV6 reduces the test time, frustration and may reduce the complication as syncope during the test which is a common observation in pregnant female, specifically last trimester.
Authors and Affiliations
Geetanjali Purohit, J. M. Harsoda
Keywords
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