Alzheimer’s Disease: Criteria for Dental Treatments
Journal Title: Journal of Clinical Medical Research - Year 2022, Vol 3, Issue 2
Abstract
Among manifestations of neurodegenerative diseases, Alzheimer Disease (AD) contributes for 60-70% to elderly dementia. AD patients suffer from impaired cognitive function and from a compromised capacity to perform activities of daily living. Neurodegenerative diseases are characterized by neuronal loss, dystrophic neurites, and cerebrovascular amyloid. AD occurs more often in woman (2/3 of AD cases) compared with men. The presence of extracellular β-amyloid peptide and hyper phosphorylated tau protein are typical of the physiopathology of the AD brain. Developed under the age of 65 years, the PSEN1 gene is located on chromosome 14q24.3. In the elderly over 65 years, the late-onset of AD, the gene coding for PSEN2 is located on chromosome 1q31-q42. For the late onset AD, the apolipoprotein E was associated to the main risk factors of developing the disease (including molecules such as clusterin, complement receptor, phosphatidylinositol binding clathrin assembly protein and sortilin). Four genes have been identified on chromosome 11. The Amyloid P Protein precursor (APP) encoded by the gene (APP) is located on chromosome 21q. Altered APP processing and Aβ accumulation shed light on the AD pathogenesis. TNFα may act as a diagnostic marker with high sensitivity and specificity in patients with AD. Studies have identified altered oral health conditions (periodontitis, caries, gingival bleeding, probing depth >4 mm). Poor gingival health and oral hygiene increase with the severity of dementia. Dental professionals should use behaviour management techniques for developing preventive strategies in order to stabilize the lesions.
Authors and Affiliations
Michel Goldberg1*
Keywords
Related Articles
- EP ID EP704387
- DOI http://dx.doi.org/10.46889/JCMR.2022.3202
- Views 85
- Downloads 0
Kohler's Disease Case Report: Treatment with Regenerative Distraction Arthroplasty Technology
Kohler’s disease is a rare condition which in most cases responds to non-operative management. This report presents an unusual case where the thinning of the navicular resulted in a symptomatic pathological fracture. The...
Optimizing Polycystic Ovarian Disorder (PCOD) Treatment with Personalized Lifestyle and Nutrition Strategies
Introduction: Polycystic Ovarian Disorder (PCOD) is a prevalent endocrine illness in women of reproductive age. It has hormonal abnormalities, irregular menstrual cycles and tiny ovarian cysts. Lifestyle and food affect...
Evaluation of Knowledge, Awareness and Attitude Regarding Clear Aligner Therapy Amongst BDS Interns: A Cross-sectional Questionnaire-based Survey
Introduction: Clear aligners are emerging as a potential treatment option in the field of Orthodontics. General dentists are usually the first ones to determine the Orthodontic needs of the patient. With an increasing de...
Selecting the Safest Public Bathroom Stall in the Era of COVID-19
COVID-19 and other respiratory diseases can be transmitted through contact with shared surfaces such as those found in public bathrooms. High-touch surfaces such as door handles, flush levers and toilet paper dispensers...
Nanoparticles in Peritoneal Carcinomatosis
The management of peritoneal metastasis remains controversial. The logo regional treatments are Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and recently the Pressurized Intraperitone...