Amanita Phalloides Avoids Tumor Growth of Leukocytes with Philadelphia Chromosome: Case Report
Journal Title: International Journal of Medical and Pharmaceutical Case Reports - Year 2017, Vol 10, Issue 3
Abstract
Background: Treatment failure in patients who have chronic myeloid leukemia (CML) using tyrosine kinase inhibitors is common due to development of secondary mutations. Amanita phalloides (Amanita) contains low dose of alpha-amanitin (amanitin),which inhibitis RNA polymerase II (RNAP) leading to slowing down of the growth of tumor cells without affecting normal cells. Aim: To determine if Amanita inhibits the growth of Philadelphia chromosome (Ph1) carrying leukocytes in CML. Methods: A patient with leukocytes carrying a Ph1 and loss of Y chromosome was treated with Amanita as the only tumor specific therapy. Pre-treatments with the tyrosine kinase inhibitors Imatinib and Nilotinib had to be terminated because of severe side effects. Monitoring was performed with blood cell count and quantitation of bcr-abl fusion transcripts. Results: The disease state could be stabilized for nearly two years until now with Amanita alone. Whereas leucocyte´s tumor growth was inhibited, and cell count remained low, the percentage of bcr-abl fusion transcripts rose. Although the relative amount of lymphocytes decreased transiently, it remained stable in the range of 1.5/nl [0.6-4.7/nl] blood. Compared to the initial phase of CML diagnosis in 2008, leukocyte count is 5 fold reduced due to the Amanita therapy. Conclusions: Amanita can inhibit tumor growth of cells carrying Ph1. However, the cells with Ph1 and loss of Y chromosome have growth advantage over the cells without these mutations. The percentage of potential tumor cells increased, but without complications.
Authors and Affiliations
Isolde Riede
A Case of Sporadic Bilateral Polythelia with High-Grade Myopia
Aim: Polythelia is a rare condition. It ıs known to be associated with urogenital anomalies. Also, there are other types of rare anomalies like hand or mandible anomalies related with this anomaly. However, our case pres...
Multidedector CT Assessment of Sinus Venosus Type Atrial Septal Defect Combined with Partial Anomalous Pulmonary Venous Return
We present two cases of sinus venosus type atrial septal defect associated with right anomalous pulmonary venous return to the superior vena cava with echocardiography and computed tomography angiography. Sinus venosus t...
Stevens-Johnson Syndrome Treated with Ozone Hemo Therapy: A Case Report
We report a case of Stevens-Johnson Syndrome treated with ozone autohemotherapy. The patient had been diagnosed with Stevens-Johnson syndrome 3 months before admission to our clinic by the treating physician. There was u...
An Unusual Case of Acute Myopericarditis Possibly Due to Food Poisoning
The manuscript describes the case of a 23 year-old woman, with acute myopericarditis associated with food poisoning without other cardiovascular disease. The patient had a history of hypothyroidism, treated with levothyr...
An Uncommon Oro-cutaneous Complication of Systemic 5-fluorouracil- A Case Report
5-fluorouracil is an antineoplastic drug mainly acts by pyrimidine antagonist and classified as an antimetabolite. There are few complications which is very rare following administration of 5FU including hyper pigmentati...