Amelioration of histological changes and associated metabolic abnormalities by a combination of Morinda lucida and metformin in diabetic rats
Journal Title: UNKNOWN - Year 2018, Vol 7, Issue 3
Abstract
This work investigates the ability of Morinda lucida and co-administration of Morinda lucida/metformin in the control of biochemical and histological changes in alloxan-induced diabetic rats. Alloxan diabetic rats were treated with 200 mg/Kg body weight of Morinda lucida leaves extract, 1 mg/Kg BW of metformin or a combination of the two treatments for 28 days. Results of the studies revealed that Morinda lucida leaves extract significantly improved lipid profile and kidney function in diabetic rats. These positive outcomes were enhanced by combined treated with Morinda lucida leaves extract and metformin. Furthermore, the calculated atherogenic index of treated animals were close to those of normal rats as opposed to diabetic rats. Similarly, histological studies showed that Morinda lucida leaves extract and metformin administered together or singly, ameliorated damages in pancreas and kidneys from alloxan diabetic rats. It can therefore be inferred that combined treatment with Morinda lucida leaves extract and merformin could improve the potency of Morinda lucida leaves used in the management of diabetic complications.
Authors and Affiliations
Atanu FO, Momoh S, Ugwu CE, Ameh O, Suleiman MS
Keywords
Related Articles
- EP ID EP589763
- DOI -
- Views 67
- Downloads 0
Phytochemical, Nutritional and Pharmacological evidences for Abelmoschus esculentus (L.)
Okra is a nutritional source of power used throughout history for both medicinal and culinary purposes. Okra is good source of minerals, vitamins and nutrients that are responsible for the health benefits. It has various...
In vitro Antimicrobial Activities of Crude Extracts of Vernonia amygdalina and Croton macrostachyus against Some Bacterial and Fungal Test Pathogens
The aim of the present study was to investigate the antibacterial and antifungal activities of crude extracts of Vernonia amygdalina and Croton macrostachyus against four bacterial pathogenic species (i.e. Staphylococcus...
Phytochemical analysis of Leucaena leucocephala on various extracts
The plants play a vital role in human life. Every plant has some disease curative properties in it. Even the fodder plants have medicinal properties. In the similar way the present research was carried out to study phyto...
Butyrylcholinsterase inhibitors from two Ficus species (Moraceae)
Alzheimer’s disease (AD) is the most common form of dementiaand mainly afflict people over 65 years of age. AD is characterized by a progressive memory loss that leads to a profound emotional disturbance in later stages....
Evaluation of the mycochemical composition and antimicrobial potency of wild macrofungus, Rigidoporus microporus (Sw).
This study examined the myochemical and antimicrobial properties of extracts obtained from Rigidoporus microporus (Sw), a wild, non- edible mushroom. Methanol and acetone extracts of R. microporus were screened qualitati...