Ameliorative Effect of Menthaspicata on Dichlorvos-Induced Oxidative Stress in the Rat Brain
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 4
Abstract
Abstract:The present study was carried out to evaluate the protective role of aqueous extract of Menthaspicata (MSE) leaf on dichlorvos (DDVP) induced oxidative stress in rat brain. Male rats were divided into 4 groups, the first group served as control (C). Group (E1) received 5.33mg/Kg BW of DDVP and group (E2) received 5.33mg/Kg BW of DDVP with MSE (100.0 mg/kg) and the group (E3) received MSE (100.0 mg/kg). Rats under all the groups were treated with their respective constituents for 30 days. The results suggested that rats under E1 suffered from significant (p<0.01) decline in the activity of superoxide dismutase, catalase, glutathione peroxidase with a significant elevation in the levels of malondialdehyde of their brain. Histological changes were also found to be prominent in the brain of E1 group as compared to others. Rats under E2 showed recuperation tendencies which were evidenced by partial restoration of antioxidant enzyme activity and the lesser degree of damage in histological aspect as compared to E1. No significant changes were observed in either biochemical constituents or histological aspects of rats under E3. The current study suggests that DDVP can cause oxidative damage and brain injury in male rats and co-administration of MSE with the selected dose partially attenuates the toxic effect caused by DDVP. Keywords: Menthaspicata, Brain, Dichlorvos, Oxidative stress and Xenobiotics.
Authors and Affiliations
David M
Keywords
Related Articles
- EP ID EP397464
- DOI -
- Views 75
- Downloads 0
Distribution of Blood Groups in Donors and Functioning Pattern of a New Semiurban Blood Bank
Abstract:Blood transfusion system is a basic necessity of health care delivery system. As off now more than 700 antigens and about 30 blood group systems have been identified. ABO and Rhesus (Rh) blood group systems are...
Causes of Nursing Faculty Turnover
Abstract: Healthcare system faced with a critical shortage of nursing faculty. One of the challenges faced by deans and directors of schools of nursing is to identify strategies that will encourage faculty to stay in aca...
Pattern of Household Cooking Fuel Use and Knowledge of It Effect on Health among Health Workers in a Tertiary Hospital in South-South Nigeria
Abstract:Household air pollution (HAP) arising from use of high polluting cooking fuel use remains a global health threat .This study sought to determine the major type of household cooking fuel used by workers ,their le...
Possible Inflammatory Responses in the Traditional Application of Raw Liquid Extract of Cnidoscolus aconitifolius Leaf (Iyana Ipaja-Chaya) In the Treatment of Anaemia
Abstract:Inflammatory response is a form of immune response which could be caused by infectious agents and toxic chemicals. Cnidoscolus aconitifolius leaf extract contains phytonutrients such as protein, vitamins, calciu...
A Calciphylaxis in a post cadaveric kidney transplant man- Case report
Abstract: We describe a case of calciphylaxis in a 54 years old man known Diabetes Type II, Hypertensive and post cadaveric transplant in the year 2000. Patient became hemodialysis dependent after the diagnosis of calcip...