Ameliorative effect on neuropathy due to anti-cancer drug using herbal extract – An experimental study of Nigella sativa
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 4
Abstract
Nigella sativa(NS) is a commonly used herb in Asian and African countries. Extensive experimental studies have been done to shed light on its hepatoprotective, immunumodulator, antioxidant, antimicrobial and several other useful pharmacological properties. However, there is dearth of evidence to evaluate the effect of Nigella sativaextract in neuropathic pain. In this study we have used neuropathic pain model of Wistar rats using intraperitoneal cisplatin injection twice weekly for 5 weeks along with daily oral ethanolic extract of Nigella sativa in test group and distilled water in control group. In our study we found significant reduction in neuropathy and neuropathic pain due to anti-cancer drug cisplatin by oral administration of ethanolic extract of Nigella sativa which was confirmed by histopathological analysis of sciatic nerve and pain assessment tests.
Authors and Affiliations
Sachchidanand Tewari, Mohd. Tariq Salman, Pretty Singh, Sukhpreet Singh
Keywords
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