AML with t(16;16)(p13.1;q22) (previous M4eos) and pulmonary aspergillosis
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2010, Vol 27, Issue 1
Abstract
The physical examination revealed pallor, purpura in the lower extremities and signs of bleeding in his gums. The full blood count revealed hemoglobin of 9.1 g/dL, a white cell count of 34×109/ L, neutrophil count of 0.7×109/L and a platelet count of 7×1012/L. Peripheral blood smears revealed the presence of abnormal cells with basophilic granules (fig. 1). Other laboratory testing was remarkable for a serum urea of 55 mg/dL, creatinine 2.1 mg/dL and LDH 2,160 U/dL. Chest X-rays revealed no abnormalities. The bone marrow aspirate was grossly hypercellular with normal hematopoiesis replaced by a population of abnormal cells, accounting for 65% of nucleated cells and eosinophils, and their precursors, accounting for 22% of nucleated cells (fig. 2). No Auer rods were seen although some abnormal cells contained fine granules. Cytochemically, these cells were positive for Sudan black and chloracetate esterase and 27% of nucleated marrow cells showed weak staining with non-specific esterase. Immunophenotyping showed positivity for myeloperoxidase, CD33, CD34, HLA-DR, CD117, CD13, CD64 and CD15, and B- and T-cell markers were negative. Cytogenetic analysis of bone marrow revealed 46,XY,t(16;16)(p13;q22) in all 20 metaphase cells. The diagnosis was made and the patient received appropriate induction chemotherapy with posaconazole prophylaxis.
Authors and Affiliations
A. SARANTOPOULOS, J. ASIMAKOPOULOS, T. CHATZILEONIDA, E. PAPAKOSTAS, M. MICHAEL, O. KAMPOUROPOULOU, N. VINIOU, K. KONSTANTOPOULOS
Keywords
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