Amniotic membrane transplantation with topical interferon alfa-2b after excision of ocular surface squamous neoplasia

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Amniotic membrane transplantation with topical interferon alfa-2b after excision of ocular surface squamous neoplasia

Journal Title: International Journal of Ophthalmology - Year 2018, Vol 11, Issue 1

Abstract

To evaluate the outcome of amniotic membrane transplantation (AMT) after tumor excision followed by topical interferon alfa-2b (IFNα2b) drops for primary ocular surface squamous neoplasia (OSSN). Twelve eyes of 12 patients with a mean age of 66±10y were included. The average follow-up was 23±10mo. All 12 patients had limbal involvement. Smooth ocular surface and transparent cornea were achieved in all cases. No sign of inflammation, neovascularization, symblepharon or recurrence was noted at the last follow-up. We conclude that AMT with topical IFNα2b drops restores a healthy ocular surface in OSSN without recurrence.

Authors and Affiliations

Ming-Chang Zhang

Keywords

amniotic membrane; carcinoma; dysplasia; interferon; ocular surface squamous neoplasia

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EP ID EP497791
DOI 10.18240/ijo.2018.01.24
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