Amoxicillin-clavulanic acid in women with preterm premature rupture of membranes and necrotizing enterocolitis in the newborns
Journal Title: Ginekologia i Położnictwo medical project - Year 2015, Vol 4, Issue 38
Abstract
Preterm premature rupture of membranes (PPROM) occurs before 37 completed weeks of pregnancy and is the cause of 30–40% of preterm births. This is due to the weakening of the structure of membranes, which is frequently induced by microbes. It carries a risk for newborns of not only many complications associated with prematurity, but also the development of sepsis, and that is why prophylactic antibiotic therapy in the case of preterm premature rupture of membranes is recommended. Therapeutic options include amoxicillin which is very often administered in combination with clavulanic acid. This medicine has been subjected to many tests in terms of the development of necrotizing enterocolitis in neonates born to mothers who have used it. However, the results of these research projects are not clear and do not allow these antibiotics to be linked to the development of such a complication in newborns.
Authors and Affiliations
Barbara Anna Kiecel-Wesołowska
Keywords
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