Amyloidosis Presenting as Severe Bleeding Diathesis
Journal Title: International Journal of Medical and Dental Sciences - Year 2017, Vol 6, Issue 2
Abstract
Bleeding is one of the rare presentations of Amyloidosis. The mechanism behind spontaneous or peri- interventional bleeding in patients of amyloidosis is complex and involves multiple co-existing factors like coagulation factor deficiency, abnormal synthesis of coagulation factors due to advanced liver dysfunction, acquired Von Willebrand disease, platelet dysfunction, amyloid angiopathy and other unknown mechanisms. We present a case of middle aged female, presenting with spontaneous retroperitoneal haemorrhage, on further investigations was found to have systemic amyloidosis and secondary severe factor X deficiency (2.7 % of normal by one stage factor assay method). Factor X deficiency (both inherited and acquired) is known to present with the most severe bleeding phenotype. The management option for such acute spontaneous haemorrhage is limited and mostly supportive in nature. Definitive treatment is directed towards the primary pathology and requires chemotherapy and hematopoietic stem cell transplantation.
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Pattern of Variations in Superficial Palmar Arch and its Clinical Importance
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Study on combined cortical thickness, total diameter of clavicle and cortical index of adult human clavicle in north Indians
Introduction: Clavicle has a complex bone structure, is variable in shape and exhibits dramatic variations both in curvatures and cross sectional geometry. Clavicle has been globally studied for purpose of generating a s...