An analysis of clinical profile and laboratory parameters in multiple myeloma
Journal Title: Indian Journal of Basic and Applied Medical Research - Year 2018, Vol 7, Issue 2
Abstract
Background: Bone marrow (BM) examination continues to be the gold standard in establishing the diagnosis of multiple myeloma (MM). Along with clinical, radiological and laboratory parameters, the histological criteria for grading and staging will help in determining the prognosis as well assist to determine the therapeutic strategies. Objectives: To evaluate and correlate the clinical and radiological findings with laboratory parameters in the diagnosis and staging of multiple myeloma in the southern part of the state of Karnataka. Materials and methods: The study was both retrospective and prospective study from January 2013 to June 2015. The clinical and radiological findings, laboratory parameters and BM examination were analyzed and correlated. Results: 50 patients were included in the study. The most common morphologic type of MM was mature myeloma followed by plasmablastic type accounting 50% and 34% each. Amongst the various prognostic variables, haemoglobin value and the presence of bone lesions in single or multiple sites were found to be statistically significant Conclusions: The patients with plasmacytic morphology have a better prognosis compared to those with plasmablastic subtype. Application of the revised International myeloma working group (IMWG) where one myeloma defining event (MDE) is adequate for the diagnosis even without the organ damage was comparable to Durie and Solomon diagnostic criteria in inclusion of the patients for the study. The Durie and Salmon criteria and staging still holds good in setups with limited resources for further management of myeloma patients.
Authors and Affiliations
Aadarsh Sharma, Swaroop N Shashidhar
Keywords
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