An Association Study of rs2829803 Polymorphism in miRNA-155 with Multiple Sclerosis in Patients Referred to Farshchian Hospital of Hamadan City, (Iran)
Journal Title: مجله علمی- پژوهشی دانشگاه علوم پزشکی قم - Year 2018, Vol 12, Issue 2
Abstract
Background and Objectives: Multiple sclerosis is a chronic autoimmune disease with inflammation of the myelin sheath of the central nervous system. A series of factors, such as environmental factors and polymorphisms have been known to be associated with it. In this study, the correlation between polymorphism of rs2829803 in miR-155 and multiple sclerosis, was investigated in the patients referred to Farshchian Hospital of Hamadan City. Methods: In this case-control study, 130 patients (29% male, 71% female) with multiple sclerosis (age range, 17-69 years) and 150 healthy subjects (38% male, 62% female) (age range, 19-63 years), were selected as the control group. Genotyping was performed by Tetra-ARMS-PCR method. Results: A significant difference was observed in the genotypic distribution of miR-155 rs2829803 in dominant form (OR: 0.33, 95% CI: 1.19-0.58) (p=0.0001) and heterozygote (OR: 1.92, 95% CI:1.17-3.16) (p=0.01) in patients compared to the healthy subjects. Conclusion: In line with previous studies on the relationship between miR-155 polymorphism (rs2829803) and multiple sclerosis disease, the results of this study confirmed the association of this polymorphism with increased risk of developing the disease.
Authors and Affiliations
Sanaz Sanaz, Soyar Soyar, Reza Reza
Keywords
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- EP ID EP467996
- DOI 10.29252/qums.12.2.28
- Views 49
- Downloads 0
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