An evaluation of anticonvulsant action of Vigabatrin on albino rats
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 1
Abstract
Abstract: Serious doubts have been cast on the original hypothesis that they may be used as a model of human absence seizures and they more probably represent a model of myoclonic seizures. The present study was planned to study the anticonvulsant action of Vigabatrin on albino rats. The current prospective study was conducted by the Department of Pharmacology of a tertiary care teaching institution. Study tools were convulsometer (electrically driven), Tuberculin syringe and Albino rats. Vigabatrin drug was used. Experimental animals were obtained from animal house of this tertiary care center. Effect of different doses of Vigabatrin against Metrazol induced convulsions was captured. Range of effective doses of Vigabatrin in 50% of animals was noted down. The peak period of Vigabatrin was determined. TD50 of Vigabatrin in the acute neurotoxicity test was ascertained. ED50 of Vigabatrin was observed to be 67 mg ± 10.20 mg/100gm of body weight. Effect of Vigabatrin starts within 60 minutes of the administration of the drug at dose of 500 mg per 100gm of body weight. The protective effect was seen maximum at 3 hours after the administration, after that the effect starts declining. TD50 of Vigabatrin was observed to be 425 mg ± 93.50 mg/100gm of body weight. Vigabatrin is relatively safe drug to use but not effective in absence seizure. Well-known side effect, visual field defect limits its use. Further elaborate screening of this drug by various experiments is needed. Keywords: Anticonvulsant action, Vigabatrin, Albino rats, Patients
Authors and Affiliations
Mohammad Imran, Abhishek Singh, Rakesh Tank, Priyamvada Sharma, Vinod Bhardwaj
Keywords
Related Articles
- EP ID EP370237
- DOI -
- Views 108
- Downloads 0
Hypogonadotropic Hypogonadism in as a Sequel of Tubercular Meningitis
The most common cause of meningitis is Tubercular meningitis (TBM) and it leads to irreparable neurological consequences, morbidity and mortality if not treated. The usual complication of TBM in survivors are neurologic...
A Study on Serosurveillance of Blood Donors
This study was undertaken to find out the seroprevalence of transfusion transmissible infections among voluntary and replacement blood donors over a period of two years. A total number of 16,872 donor’s blood units were...
University Students’ Knowledge, Awareness, and Perception on Tuberculosis (TB) Disease: A Literature Review
Abstract: Having knowledge of tuberculosis disease (TB) in each individual person is important in terms of understanding the signs and symptoms, spread of disease, and treatment of the disease in order to terminate the T...
Effect of Oral Administration of Lead Acetate Exposure on the Histology of the Testis and Testicular Sperm Concentration in Wistar Albino Rats
Abstract: Lead is a heavy metal found in all environmental components such as earth crust, air and water.. The present study evaluates the effect of lead acetate on the histology of the testis and testicular sperm concen...
Spontaneous Regression in Herniated Lumbar Disc: Mechanism and Prognostic factors
Although there are publishings about the natural course of lumbar disc herniation, the natural course of this disease has not been proved literally. Spontaneous regression, which can be seen in natural course of lumbar...