AN EVALUATION OF IMPACT ON QUALITY OF LIFE IN PATIENTS ON ANTIPSYCHOTIC THERAPY AT A TERTIARY CARE CENTRE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 20
Abstract
BACKGROUND Antipsychotic drugs utilisation is expanding step by step due to lifestyle changes and increased stress in day-to-day along with psychiatric disorders. Prevalence of Adverse Drug Reactions (ADRs) with antipsychotic drugs is high, which is influencing the quality-of-life of patients more than the underlying disease. Hence, this study was taken up to assess Impact on Quality-of-life in patients using antipsychotics. MATERIALS AND METHODS A prospective observational study was carried out in the Department of Psychiatry at Erragadda Hospital, Hyderabad for 6 months. A total of 189 patients on Antipsychotics were enrolled and Baseline Quality-of-life (WHOQOL-BREF) scale was recorded. On a fixed day in a week they were screened for ADRs, 126 adverse drug reactions (ADRs) occurred. ADRs were monitored using causality assessment scale of Naranjo algorithm. The WHOQOL-BREF scale was used to study the quality-of-life. RESULTS The physical and psychological domain scores of WHO-QOL BREF decrease in patients with ADRs compared to without ADRs. Of the total 189 patients, 126 ADRs occurred. Adverse drug events were mostly with olanzapine (83) followed by risperidone (71) owing to high usage in the government hospital. Majority of the events were classified as probable (34). CONCLUSION The study provides information on the influence of Quality-of-life patients on antipsychotics due to ADRs. Psychiatrists and other health care professionals treating psychiatric patients ought to have information about the possible ADRs and their influence on Quality-of-life following antipsychotic medication and thus should keep an active vigil to prevent, treat and alleviate the adverse health effects due to ADRs.
Authors and Affiliations
Hima Bindu Ellabathini, Arun Jyothi Gaddameedi
Keywords
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