An Evaluation of the Efficacy of Clonazepam in Patients with Burning Mouth Syndrome in comparison with Lycopene: A Double-Blinded clinical Study
Journal Title: International Journal of Medical Science and Diagnosis Research (IJMSDR) - Year 2018, Vol 2, Issue 5
Abstract
Burning mouth syndrome (BMS) as defined by the International Association for the Study of Pain is the burning pain in the tongue or other oral mucous mem¬brane that are associated with normal signs and laboratory fin¬dings lasting at least 4 to 6 months. This study was designed to evaluate the clinical efficacy of clonazepam in comparison with lycopene in treating patients with burning mouth syndrome (BMS). Thirty patients were randomized into two groups equally. Group-1 was administered with Clonazepam at a dose of 0.25mg before bed for 1 week, with escalation of the dose by no more than 0.25 mg each week to a maximum dose not greater than 3.0 mg per day in 3 divided doses. Group-2 was administered with lycopene 4 mg twice daily for a period of 8 weeks. The patients were evaluated by the severity of burning sensations using a 10-point visual analog scale (VAS: 0-10; 0=no burning sensation and 10= worst possible burning sensation) and follow-up visits at 2, 4, 6 and 8 weeks to assess the score. The subjects comprised of 10 males and 20 females with an average age years. The results of this study showed that there was reduction in burning sensation significantly at subsequent follow up visits at 2nd, 4th, 6th and 8th weeks in both the groups but these changes were much more pronounced in patients receiving Clonazepam compared to patients receiving Lycopene Clonazepam has been found effective on pain in patients with burning mouth syndrome and there has been no major side effects that would severely restrict its application. Key words: Burning mouth syndrome, Clonazepam, Lycopene
Authors and Affiliations
Bashir Ahmad Wani
Keywords
Related Articles
- EP ID EP547607
- DOI -
- Views 53
- Downloads 0
Assessment of awareness towards generic and branded drugs among resident doctors and clinicians of a tertiary care hospital
Background: Doctors frequently face the problem of decision making regarding choice of prescribing branded or generic drugs. This cross-sectional questionnaire based study was designed to assess the awareness among clini...
Indian Medical Graduate – Expectations and Reality
For a country like India, a competent and skillful medical graduate is need of the hour. Indian medical colleges are often criticized are producing graduates who are not well equipped to tackle the health care needs of t...
“Factors of raised C-reactive protein as a potential determinant of Diabetic patients and Risk factor for Coronary Heart Disease”
Elevated C-reactive protein (CRP) levels have previously been described before the onset of type 1 diabetes and gestational diabetes. We hypothesized that inflammation, as reflected by elevated CRP levels, can help predi...
METABOLIC ACIDOSIS: A RISKFACTOR INACUTE KIDNEY INJURY
Background: Metabolic acidosis has been proved to be a risk factor for the progression of chronic kidney disease, but its relation to acute kidney injury (AKI) has not been investigated. The objective of this study was...
An evaluation of the sensitivity, specificity and positive predictive value of CB-NAAT testing in the diagnosis of Tuberculous Pleural Effusion
The diagnosis of TB pleural effusion with microbiological confirmation is a challenging task it being a paucibacillary infection and most cases are diagnosed clinically and empirically started on anti tubercular drugs. W...