An evaluation of the serum biomarkers of Endothelial dysfunction in hypertensive and hypercholesterolemic subjects: A case-control study
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 11
Abstract
Objective: To evaluate the serum biomarkers of Endothelial dysfunction in hypertensive and hypercholesterolemic subjects. Methods: This was a case-control study conducted in a tertiary care hospital. The patients with hypertension and hypercholesterolemic were diagnosed using 7th Joint National Committee criteria. The cases were with primary Hypertensive and hypercholesterolemic patients without any other complication. Controls were healthy subjects without any complication. A total of 60 cases and 30 controls were included in the study. Results: More than one third of patients of both cases (41.7%) and controls (43.3%) were above 60 years of age. More than half of patients of both cases (60%) and controls (56.7%) were males. There was no significant difference (p>0.05) in age and gender between cases and controls showing comparability of the groups in terms of age and gender. A significant (p=0.0001) increased level of total cholesterol, LDL and triglrcerides was observed among cases compared to controls. However, significant (p=0.004) decreased level of HDL was found among cases than controls. Serum uric acid, creatinine, nitric oxide, hs-CRP and IL-6 were significantly (p=0.0001) increased among the cases than controls. Conclusion: Endothelial dysfunction is an important component of primary hypertension as well as that of hypercholesterolemic state, the severity being determined by nitric oxide, hs-CRP, LDL cholesterol and HDL cholesterol levels independently
Authors and Affiliations
Dr Amit Kumar
Keywords
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