AN EXPERIMENTAL STUDY EVALUATING THE INFLUENCE OF BISPHOSPHONATES ON DEPRESSION PATTERNS IN SWISS ALBINO MICE AND WISTER RATS

Abstract

Objective: Bisphosphonates are used for treating osteoporosis. Few studies have reported their effect on alterations in comorbid behaviour such as depression. Therefore, present study was performed to investigate the effects of bisphosphonate drugs on depression in adult male Wister rats and Swiss albino mice.Methods: The study was conducted on adult male Wister rats and Swiss albino mice, 36 of each type, equally divided into six groups. One group was classified as control group and the rest were treated as test groups. Initial photoperiod of 12 h was provided for acclimatization, prior to the start of the experiment. Drug administration was not performed in control group. Forced swimming test and tail suspension test were performed to investigate the antidepressant activity. Locomotor activity was performed to evaluate the action of drugs on the nervous system. Effects of the test drugs were compared with a standard drug—amitriptyline. Results were statistically evaluated by one-way analysis of variance followed by Bonferroni’s multiple comparison test. P≤0.05 was considered significant.Results: In forced swimming test, duration of immobility was significantly reduced in the standard and test drugs when compared to control group; however, it was not significant in all the four test groups as compared to that of amitriptyline-administered group (p>0.05). In tail suspension test, significant decrease (p<0.01) in the duration of immobility was observed with administration of drugs when compared to control group. Results of test groups were not found to be significant as compared to amitriptyline-treated group (p>0.05). Mean values of amitriptyline-, alendronate-, risedronate-, ibandronate-and etidronate-treated groups failed to show significant difference (p>0.05) when compared to control group suggesting homogeneity among the groups.Conclusion: Bisphosphonates appeared to have an antidepressant activity. More extensive research is required to substantiate and elucidate the role of bisphosphonates in behavioural disorders such as depression.

Authors and Affiliations

Amitha N, S. S. Torgal

Keywords

Related Articles

PRELIMINARY INVESTIGATIONS INTO THE PHYSICOCHEMICAL AND COMPACTION CHARACTERISTICS OF MODIFIED STARCH OF DISCOREA ALATA USING DICLOFENAC SODIUM TABLET

Objective: This work focused on evaluating the micromeritic and compressional properties of pregelatinized African water yam (Discorea alata) starch and its modified forms with comparison to pregelatinized corn starch an...

VALPROIC ACID INDUCED TRANSAMINITIS

Valproic acid (VPA) is a broad spectrum antiepileptic agent used in the treatment of absence, myoclonic, partial and tonic clonic seizure and also used in the treatment of bipolar disorder. Although VPA, a proven anticon...

INVESTIGATIONS ON NOVEL BIO-BINDER ISOLATED FROM AEGLE MARMELOS USED IN IBUPROFEN TABLETS

Objective: Binders are agents used to impart cohesive qualities to the powdered material during the production of tablets. Thus the aim of present research work was to formulate the oral tablets of Ibuprofen by using Aeg...

DEVELOPMENT AND EVALUATION OF IN SITU NASAL MUCOADHESIVE GEL OF METOPROLOL SUCCINATE BY USING 32 FULL FACTORIAL DESIGN

Objective: To develop and evaluate in situ nasal mucoadhesive gel of metoprolol succinate.Methods: In situ nasal mucoadhesive gel was formulated by cold method using Carbopol 940 as a pH sensitive polymer, xanthan gum as...

ENHANCEMENT OF STABILITY, RELEASE AND IN VITRO DIGESTIBILITY OF MULBERRY STEM EXTRACT USING MICROEMULSIONS

Objective: This study was aimed to develop oral microemulsions and to evaluate their ability to enhance stability, release and intestinal digestion of mulberry stem extract (MSE).Methods: The pseudoternary phase diagrams...

Download PDF file
  • EP ID EP575577
  • DOI 10.22159/ijpps.2017v9i8.18829
  • Views 68
  • Downloads 0

How To Cite

Amitha N, S. S. Torgal (2017). AN EXPERIMENTAL STUDY EVALUATING THE INFLUENCE OF BISPHOSPHONATES ON DEPRESSION PATTERNS IN SWISS ALBINO MICE AND WISTER RATS. International Journal of Pharmacy and Pharmaceutical Sciences, 9(8), 187-191. https://europub.co.uk/articles/-A-575577