An eye in a culture dish: ocular organoids and their application
Journal Title: Eye Science (Yanke Xuebao) - Year 2022, Vol 37, Issue 2
Abstract
Being one of the most important sensory organs, the eye is composed of the cornea, the lens, which are responsible for refraction, and the retina, which is the neural sensory part of the eye. Various kinds of developmental abnormalities and functional defects could lead to visual dysfunctions, and even blindness. Current treatments for blindness-causing eye diseases all have their own limitations, awaiting new efficient diagnostic and treating methods. Thanks to the development in stem cell biology and bioengineering, taking advantage of the rich knowledge accumulated on the mechanisms governing eye development, researchers have successfully generated various ocular organoids using multiple sources of stem cells in vitro, which resemble their counterparts in vivo on both the structural level and functional level. Ocular organoids provide valuable material and models for studying eye development, pathology, drug screening, and cell replacement therapy, pushing translational studies of ocular stem cell to a new era. Here, the paper reviews the development and application of ocular organoid technologies.
Authors and Affiliations
Jinyan LI, Lixia LUO, Yizhi LIU, Shuyi CHEN
Keywords
Related Articles
- EP ID EP763628
- DOI 10.3978/j.issn.1000-4432.2021.07.23
- Views 14
- Downloads 0
Clinical presentation and outcomes of rhegmatogenous retinal detachment in phakic eyes after posterior chamber phakic intraocular lens implantation for high-myopia
[Objective:] To analyze the clinical presentation, surgical management, and outcomes of rhegmatogenous retinal detachment (RRD) in patients with high-myopia corrected by posterior chamber phakic (PCP) intraocular lens (I...
A qualitative study of home care and nursing needs of patients with severe acuity impairment or blindness
[Objective:] To explore the main nursing problems and demands of patients with severe visual impairment or blindness, so as to provide the basis for health staff to formulate home care support plans of high quality. [Met...
Research progress on associated factors and prediction of glaucoma-related adverse events following secondary intraocular lens implantation in pediatric eyes
Pediatric cataract is one of the leading causes of treatable childhood blindness worldwide. For these children, surgery is the primary method to restore or preserve vision. However, postoperative complications, particula...
Retinal changes in pre-diabetes and pre-clinic diabetes retinopathy
Diabetes retinopathy (DR) is the main cause of visual impairment in the working population worldwide. Patients with pre-diabetes and pre-clinic diabetic retinopathy are regarded as in high risk group of DR. The changes i...
Clinicopathological analysis of 10 cases of pigment nevus of lacrimal caruncle complicated with squamous cell papilloma
[Objective:] To analyze the clinical pathologic characteristics of pigment nevus of lacrimal caruncle complicated with squamous cell papilloma. [Methods:] This is retrospective case series study including ten patients di...