An Immunohistochemical Study of P53 and Bcl2 in Synchronous Colorectal Adenomas and Adenocarcinomas – A Study from South India
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 12
Abstract
Adenomatous polyps are the commonest types of polyps of the large intestine. The malignant potential of these polyps has been studied by Vogelstein et al, who proposed the classic adenoma-carcinoma sequence. Other mechanisms such as microsatellite instability and hypermethylation have also been proposed in recent times in the pathogenesis of colorectal carcinomas.Aim: To study (1)the incidence and morphology of colorectal adenomas in a large hospital-based population (2)the incidence of non-contiguous colorectal adenocarcinomas occurring synchronously with colorectal adenomas (3) the expression of p53 and bcl-2 in polyps occurring synchronously with and without cancers. Materials and methods: All colorectal adenomatous polyps were included in the study. The incidence and morphology of colorectal adenocarcinomas occurring synchronously with the adenomatous polyps were analysed.Immunohistochemical expression of p53 and bcl-2 were studied in 16 cases of polyps occurring with non-contiguous cancers and matched control group of polyps. Conclusion: 120 colorectal adenomatous polyps were studied, of which 16 cases showed co-existent noncontiguous adenocarcinomas. P53 & bcl2 were found to be higher in proportion in the “polyp with co-existent cancer” group than the “polyps alone” group. However, the difference in expression between the 2 groups were not statistically significant.P53 and bcl2, though are involved in malignant transformation, cannot be used as predictive markers for development of malignancy in adenomatous polyps. Study of more molecular markers may be necessary to explain colorectal carcinogenesis in adenomatous polyps.
Authors and Affiliations
Shanthi Velusamy, Geetha Devadas
Keywords
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- EP ID EP421671
- DOI 10.9790/0853-1712040104.
- Views 56
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