An In-Vitro Evaluation of Antifungal Effect of Tissue Conditioner Incorporated With Hydroalcoholic Leaf Extract of Acacia Nilotica.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 3
Abstract
Topical antifungal therapy for denture stomatitis is challenging to apply in geriatric denture-wearers due to reduced motor activity, cognitive impairment, and memory loss. With the overuse of synthetic antimicrobials, the emergence of multi-drug resistant (MDR) strains of micro-organisms have increased. The herbal extracts of Acacia nilotica have been proven effective against MDR Candida albicans and streptococcus mutans. Purpose: The aim of this study is to evaluate antifungal effect tissue conditioner incorporated with Acacia nilotica leaf extract. Method: A hydroalcoholic extract of leaves of Acacia nilotica was prepared using cold maceration technique. Minimum inhibitory concentration (MIC) of the extract was evaluated using serial dilution method. The extract was incorporated into the tissue conditioner at MIC and then subjected to antifungal efficacy by disk diffusion method. A total 60 samples with dimension of 5mm diameter and 1 mm thickness were fabricated i.e. 20 control samples (CT group), 20 samples of tissue conditioner incorporated with Acacia nilotica (AT group) and 20 samples of tissue conditioner incorporated with nystatin (NT group). Each group was further subdivided according to the time interval of evaluation which is after 24 hours and after 14 days. Thus, each subgroup comprised of 10 samples. Result: Hydroalcoholic leaf extract of Acacia nilotica have a potential antifungal activity. One-way ANOVA and Tukey’s Post hoc test were used for statistical analysis. Conclusion: Incorporation of hydroalcoholic leaf extract of Acacia nilotica into the tissue conditioner can prove to be beneficial to improve oral health status of the geriatric patients.
Authors and Affiliations
Jayprabha Bafna
Keywords
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