An Indolent Natural Killer Cell Leukemia Presenting with Bilateral Ankle Arthritis and Low Grade Fever
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 6
Abstract
NK-cells are morphologically similar to other lymphocytes but immunologically different from them. They have variable expression of one or other T-cell markers but essentially not expressing surface or cytoplasmic CD3 except a minor population of cytoplasmic epsilon CD3.Clinically neoplasm of NK-cell presents as either aggressive or indolent lymphoma/leukemia behaving differently from neoplasm of T-cell and B-cell. Till now treatment protocol is not well-defined and effective for this resistant type lymphoma/leukemia. In this case, patient presented with low grade fever and bilateral ankle arthritis and NK-cell lymphocytosis in peripheral blood and bone marrow. Because NK-cell leukemia is rare and presentation of this case is not totally fitting in aggressive or indolent variant of NK-cell leukemia, thus I report this case.
Authors and Affiliations
Subhash Chandra Jha
Keywords
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