An Investigation of the Frequency of HBsAg, and Anti-HCV Including Their Effects on Some Biochemical Parameters among University Students Presenting with Malaise
Journal Title: Scholars Academic Journal of Biosciences - Year 2016, Vol 4, Issue 10
Abstract
Hepatitis B and C viruses cause viral hepatitis which could affect the function of the liver. Viral hepatitis is one of the major killer diseases associated with malaise but could be prevented. This work was designed to investigate the frequency of HBsAg, and anti-HCV including their effects on some biochemical parameters among University Students presenting with malaise. Fifty malaise University students were recruited through their Health Centre. The students were screened for anti-HCV, anti-HIV and HBsAg Immunochemical by ELIZA and Immunoblotting. Total Bile acid and Total Antioxidant were determined by spectrophotometry. Immune status was determined using CD4 count by Cyflowmetry. The results obtained showed an overall frequency of 8(16%) HBsAg seropositive, 5(10%) anti-HCV seropositive , 7(14%) HBsAg and anti-HCV seropositive, 30(60%) HBsAg or and anti-HCV seronegative students. Mono infection of hepatitis B virus and its coinfection with hepatitis C virus were more prevalent in female students than their male countapart while hepatitis C virus infection was more prevalent in males than the female students. Total bile acid in anti-HCV seropositive students was significantly higher than in HBsAg seropositive students and in HBsAg and anti-HCV seropositive students than those who were anti-HCV seropositive also in HBsAg and anti-HCV seropositive students than HBsAg and anti-HCV seronegative students with p<0.05 Total antioxidant anti-HCV seropositive students was significantly lower than in HBsAg seropositive students ; also in HBsAg seropositive patients than in HBsAg and anti-HCV seronegative patients with p<0.05. There was also a significantly lower plasma Total antioxidant in HBsAg and anti-HCV seropositive students than in anti-HCV seropositive students and in students with anti-HCV , HBsAg + anti-HCV seropositive than in students who were sero negative to anti-HCV and HBsAg + anti-HCV with p<0.05. CD4 count was significantly lower in anti-HCV seropositivestudents than HBsAg seropositive students and than HBsAg + anti-HCV seronegative students; also in HBsAg + anti-HCV seropositive students than HBsAg + anti-HCV seronegative students with p<0,05. Biochemical alteration on antioxidant, total bile acid and CD4 count was more in HCV and students coinfected with HBV-HCV. The overall frequency of 8(16%) HBsAg seropositive, 5(10%) anti-HCV seropositive, 7(14%) HBsAg and anti-HCV seropositive, 30(60%) HBsAg or and anti-HCV seronegative students. More female students were mono and coinfected with HBV and HCV. Mono-infection of HCV was more prevalent in male than female students. Keywords: frequency, HBsAg,, anti-HCV, University Students, malaise, Total Bile Acid, Total Antioxidant, CD4
Authors and Affiliations
Mathew Folaranmi Olaniyan
Keywords
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