An observational study of treatment outcome in cutaneous systemic sclerosis
Journal Title: International Journal of Clinical Rheumatology - Year 2017, Vol 12, Issue 2
Abstract
Objective: An observational method was used for estimation of the effectiveness of different current treatment regimens on skin thickening of PSS. Method: 34 patients of scleroderma were treated with cyclophosphamide-MMF (15); cyclophosphamide-AZA (4); MMF (3), cyclophosphamide (3); Azathioprine (1.8) were only on sildenafil. The primary outcome measure was Modified Rodnan Skin Score (MRSS). Result: The study included 34 patients. 15 patients were on cyclophosphamide followed by MMF. MRSS improved from mean 20.33 to 16.07. 4 patients treated with cyclophosphamide followed by AZA, MRSS improved from mean 23 to 16. 3 patients on MMF alone, MRSS improved from mean of 10.33 to 8. 3 were only on cyclophosphamide MRSS improved from 17 to 15 (mean). One patient was on Azathioprine, MRSS improved from 6 to 4. 8 patients were only on Sildenafil for Raynaud’s phenomenon and MRSS worsened from mean 12 to 13.38. Conclusion: Improvement observed in all regimens of immunosuppressant and skin thickening worsened in those without on any immunosuppressant.
Authors and Affiliations
Mushtaq Ahmad, Fayaz Ahmad Sofi, Ashiq Hussain Parrey, Bilal Ahmad Rather
Keywords
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