An Observational Study on the Prevalence of Metabolic Syndrome in Reproductive Aged Women with PCOS
Journal Title: Indian Journal of Obstetrics and Gynecology - Year 2018, Vol 6, Issue 6
Abstract
Background: Polycystic Ovarian Syndrome (PCOS) is a heterogeneous, multifactorial, polygenic endocrine condition seen in women of reproductive age group. The diagnosis of PCOS is made based on Rotterdam’s criteria 2003 (Any two out of the following three-Oligoovulation and/or Anovulation, Hyperandrogenism, Polycystic ovaries). Hyperinsulinemia and Insulin resistance contribute to the basic pathogenesis of PCOS. Aims: The present study aims to study the prevalence of metabolic syndrome in PCOS in reproductive aged women. Settings and Design: Observational study. Materials and Methods: All the women aged 15 to 40 years attending the gynaecology OPD diagnosed with PCOS based on Rotterdam’s criteria during the study period of one year with a sample size of 146 were included in this observational study. After getting informed written consent from these patients,detailed history of age, parity, socioeconomic status, menstrual, marital, obstetric, past, personal and family history were obtained. They were screened for metabolic syndrome according to the modified American Heart Association / National Heart Lung Blood Institute modified ATP 111 definition 2001 which defines metabolic syndrome as the co-occurrence of three or more of the following risk factors (i) central obesity with waist circumference ³ 88 cm in women, (ii) elevated systolic and/or diastolic blood pressure of ³130/85 mmHg, (iii) impaired fasting serum glucose ³110 mg/dL, (iv) elevated fasting serum triglycerides ³150 mg/dL, and (v) fasting high-density lipoprotein (HDL) cholesterol <50 mg/dL. Statistical Analysis used: Statistical analysis was done using SPSS version 25. Continuous variables were summarized as mean with standard deviation and analyzed using sample t-test. Categorical variables were expressed as proportions and analyzed by Chi-square test. Results: The prevalence of metabolic syndrome in PCOS was 38.4%.The occurrence of metabolic syndrome was more in the age group 26 to 35 years (62.33%). Central obesity with waist circumference ³ 88 cm in women, elevated systolic and/or diastolic blood pressure of ³130/85 mmHg,impaired fasting serum glucose ³110 mg/dl, elevated fasting serum triglycerides ³150 mg/dL, and fasting high-density lipoprotein (HDL) cholesterol <50 mg/dl and the ultrasound features of PCOS were observed to be statistically significant.No significant association was observed with hyperandrogenic clinical features and PCOS in USG in our study. Conclusion: The prevalence of metabolic syndrome in our study was 38.4%, which obviates the necessity of routine screening for metabolic syndrome in women with PCOS attending the gynaecology outpatient department. The study outcome can be utilised to prepare a screening protocol for metabolic syndrome, especially in low resource centres.
Authors and Affiliations
N. Prema .
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- EP ID EP550170
- DOI 10.21088/ijog.2321.1636.6618.3
- Views 63
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