An Overview of Guillain-Barre Syndrome with Reference to Cerebrospinal Fluid Analysis and Electrodiagnostic Study at Urban Areas of Madhya Pradesh
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 3
Abstract
Abstract: Guillain-Barre Syndrome is the commonest cause of acquired demyelinating disorders affecting the peripheral nervous system in any part of the world. It is a spectrum of illness of diverse etiology with a common pathological process. It is a non-seasonal illness affecting persons of all age groups. The severity of Guillain-Barre Syndrome varies from mild weakness to total paralysis and respiratory failure, sometimes leading to death. Predominantly study conducted at Govt. District Hospital, Ratlam & also covered rural population of Ujjain & Indore & its surroundings. It offers medical management to all economic status of people, all religions and all age groups. It is more ideal to conduct a study in this institution. The diagnosis of Guillain-Barre Syndrome is made predominantly by clinical examination and aided by investigations like cerebrospinal fluid analysis and electrodiagnostic studies. 80% of Guillain-Barre Syndrome patients recovered smoothly without going for complications. 30% of Guillain-Barre Syndrome patients developed respiratory muscle weakness of varying severity. 40% of patients showed features of autonomic disturbance of varying severity. 2 patients had features suggestive of ocular muscle involvement and in 1 patient feature of incordinationwas present. Prognostic outcome in our study is somewhat poor with increasing age. Prognostic outcome is poor when there is co-existing illness like diabetes mellitus or ischemic heart disease. Cerebrospinal fluid analysis in patients the Guillain-Barre Syndrome who had increased protein correlated with severe demyelination in electrodiagnostic studies and delayed recovery. Prognosis in patients the Guillain-Barre Syndrome linearly varies with severity of electrodiagnostic studies. H-reflex was invariably absent in all those patients included in the study. F-response was absent in 90% of patients in lower limbs and 70% of patients in upper limbs. Reduction in motor nerve conduction velocity was noted in all these patients of varying severity. A feature of conduction block was noted in patients with severe weakness. Recovery was delayed in patients with conduction block than in patients with delayed motor nerve conduction velocity alone.
Authors and Affiliations
Dr. Anand Chandelkar, Dr. Arun Chandelkar
Keywords
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