AN OVERVIEW OF MOUTH DISSOLVING FILMS: FORMULATION ASPECTS
Journal Title: International Journal of Pharmaceutical and Biological Science Archive - Year 2017, Vol 5, Issue 5
Abstract
These films generally dissolve within seconds to release the active agents but can be modified to release the drug more slowly depending upon film thickness and selection of the polymer matrix. A film or strip can be defined as a dosage form that employs a water dissolving polymer which allows the dosage form to quickly hydrate, adhere and dissolve when placed on the tongue or in the oral cavity to provide rapid local or systemic drug delivery. Upon complete disintegration, absorption of the API may occur through the buccal mucosa. Esophageal absorption may also occur during the process of swallowing saliva that contains the dissolved API. The majority of the dose ultimately ends up in the stomach and is absorbed in the GI tract in a similar manner as a traditional tablet. A traditional oral dosage form requires a fixed amount of time for stomach fluids to dissolve the entire tablet or capsule. This review article was based on the discussion of various formulation aspects of mouth dissolving films and their additives. KEYWORDS: Mouth dissolving dosage forms (MDDF), properties, fabrication, additives.
Authors and Affiliations
Dr. Manish Kumar Gupta
Keywords
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