AN OVERVIEW ON NON STEROIDAL ANTI-INFLAMMATORY DRUG AS A TRIGGER OF CARDIOVASCULAR DISEASE.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 1
Abstract
Nonsteroidal anti inflammatory drugs which are widely used by elderly patients. It have undesirable side effect including ulcers, bleeding, kidney failure and raised risk of heart and stroke. Mechanism of action, prolonged exposure to any class of non steroidal anti inflammatory drugs has been shown to have potential adverse effects on cardiovascular events in patients with or without pre existing cardiovascular conditions, depending on the duration and dosage of these drugs. Patient which having pre-existing coronary artery disease, hypertension, and history of stroke are at the higher risk of cardiovascular disease after taking non steroidal anti inflammatory drugs. The use of non steroidal anti inflammatory drugs with other antiplatelet drugs (except aspirin) increased the rate of cardiovascular events.Cyclooxygenase-2 inhibition results in a reduction of prostaglandin synthesis and is associated with both anti natriuretic and vasoconstrictor effects. Inhibition of cyclooxygenase-2 may lead to reductions in both prostagladinE2 and prostacyclin. Inhibition of ProstaglandinE2 may promote an acute relative reduction in daily urinary sodium excretion. The kidneys in patients with normal kidney function will tend to increase sodium excretion to compensate for the antinatriuretic effects of the Cyclooxygenase-2 selective inhibitor or Non steroidal anti inflammatory drug to maintain homeostasis of sodium balance. This phenomenon occurs in lack of a elevation in blood pressure or sustained rise in plasma volume. Suppression of the Cyclooxygenase -2?dependent formation of prostaglandinI2 by the coxibs might influence in patients to myocardial infarction or thrombotic stroke. Thus, reduction in prostaglandinI2 formation, lead to a expected elevation of blood pressure, accelerate atherogenesis, patients receiving coxibs to an exaggerated thrombotic response to the rupture of an atherosclerotic plaque.
Authors and Affiliations
Jossy P Jose, Shanmuga Sundaram Rajagopal, Sambath kumar Ramanathan.
Keywords
Related Articles
- EP ID EP276727
- DOI 10.21474/IJAR01/6408
- Views 85
- Downloads 0
DYNAMIC HYSTERESIS LOOP OF A FERROMAGNETIC LAYER: EFFECT OF THE HIGH SECOND ORDER OF THE ANISOTROPY CONSTANT.
Dynamic magnetization reversal measurements at room temperature have been performed by magneto-optical effect on Au/Co/Au sandwiches with perpendicular anisotropy. Domain wall displacement and domain nucleation regimes g...
NIGERIA CUSTOM SERVICE, INTER-AGENCY COOPERATION AND NATIONAL SECURITY.
Cooperation among security agencies is vital and of paramount importance to national security. Loose or poorly managed border posts particularly when there is no harmonious relationship among security agencies hinders ef...
PNEUMATOCYST COMPLICATING A GIANT NECROTIC MACROPROLACTINOMA: ABOUT A VERY RARE CASE.
Treatment of patients with giant and invasive macroprolactinomas consists of dopamine agonists (cabergoline or bromocriptine). When they reduce the size of invasive prolactinomas, the intra and extra cranial spaces may c...
INTERNET USAGE OF THE SHS STUDENTS OF LCUP AND ITS IMPACT ON THEIR HABITS AND ATTITUDES.
Internet, as we know it at present, started to assemble a link between and among networks around the world. The advent of the world wide web (www) in the 1990s changed the lifestyle and norms of the computer-age generati...
VERNEUILS DISEASE.
Verneuil\\\'s disease is a chronic fistulating, sclerosing and scar-forming suppuration. Its diagnosis is often misunderstood and therefore mistaken for another pathology. Through the analysis of 13 observations of Verne...