AN OVERVIEW ON TECHNIQUES IMPLEMENTED FOR DISSOLUTION ENHANCEMENT OF ACECLOFENAC
Journal Title: Journal of Biological and Scientific Opinion - Year 2013, Vol 1, Issue 4
Abstract
Aceclofenac is aceclofenacum (O–(2, 6-dichloroaniline) phenyl] acetate glycolic acid ester, 2–(2, 6-dichloraniline) phenyl acetoxy acetic acid. Aceclofenac is a Non- Steroidal Anti Inflammatory drug. It is used in the management of osteoarthritis, rheumatoid arthritis and ankylozing spondylitis. Aceclofenac when taken orally shows gastrointestinal disturbances such as GI discomfort, nausea, diarrhea due to its low solubility, in some patient’s peptic ulceration and severe gastrointestinal bleeding may also occur. Thus various approaches have been used to overcome problems like gastric irritation and other side effects that are frequently experienced with NSAID drug therapy. Aceclofenac is practically insoluble in water leading to poor dissolution and variable bioavailability upon oral administration. Aceclofenac needs enhancement of solubility and dissolution rate to improve its oral bioavailability and therapeutic efficacy. In order to improve solubility and dissolution of poorly water-soluble drug several methods are used. Enhancing the bioavailability of poorly water-soluble drug, selection of the carriers is of the most challenging aspect of drug development. Now a days different techniques are available to enhance the solubility of drug like co-solvent, solid dispersion, chemical modification of drug, liquid solid technique etc. The review article comprises of the research materialized in the field of solubility and dissolution enhancement of aceclofenac.
Authors and Affiliations
Vikramjeet Singh, Mahesh Kataria, Ajay Bilandi
Keywords
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- EP ID EP115497
- DOI 10.7897/2321–6328.01421
- Views 307
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