AN UPDATE ON TREATMENT OF ALZHEIMER DISEASE- A LITERATURE REVIEW
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 7
Abstract
Alzheimer’s disease represents an enormous global burden in terms of human suffering and economic cost. It is the most common cause of dementia all over the world. The pathological hallmarks of Alzheimer's disease are amyloid plaques and neurofibrillary tangles. The goal of this review is to discuss early diagnosis using biomarkers and newer treatment strategies for Alzheimer's disease. Newer strategies focus on employing disease modifying agents targeting amyloid cascade. The aim of such treatment is to reduce amyloid production, prevent tau hyperphosphorylation, aggregation and improve clearance of both tau and amyloid. Cholinesterase inhibitors and Memantine are the only drugs approved for treatment as yet. Although they improve symptoms they do not cure or totally halt the progression of illness. Nutritional supplements, physical activity plays a role in prevention according to few studies, but their role has not yet been approved.
Authors and Affiliations
Dr. Sadia Sultan
Keywords
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- EP ID EP637777
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