An Update Review of Animal Models For Experimental Periodontal Diseases
Journal Title: Indian Journal of Dental Advancements - Year 2015, Vol 7, Issue 4
Abstract
Animal models and cell cultures have contributed new knowledge in biological sciences, including Periodontology. Although cultured cells can be used to study physiological processes that occur during the pathogenesis of periodontitis, the complex host response fundamentally responsible for this disease cannot be reproduced in vitro. Among the animal kingdom, rodents, rabbits, pigs, dogs, and nonhuman primates have been used to model human periodontitis, each with advantages and disadvantages. Periodontitis commonly has been induced by placing a bacterial plaque retentive ligature in the gingival sulcus around the molar teeth. In addition, alveolar bone loss has been induced by inoculation or injection of human oral bacteria (e.g., Porphyromonas gingivalis) in different animal models. A practical and highly reproducible model that truly mimics the natural pathogenesis of human periodontal disease has yet to be developed.
Authors and Affiliations
Mounika Basavaraju, Vidya Sagar Sisinity, Raja Babu P, Pavan Kumar Addanki
Keywords
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- EP ID EP496674
- DOI 10.5866/2015.7.10268
- Views 116
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