An Urinary Excretion Profile of 500 mg Ascorbic Acid in Healthy Adults
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2012, Vol 1, Issue 2
Abstract
High doses of ascorbic acid have been commercially available as adjuvant. However, the pharmacological importance of this supplement is yet questionable. The aim of this study is to investigate the 24 hours excretion profile of ascorbic acid after oral administration of 500 mg single dose in healthy volunteer. The urine samples were collected at 2, 4, 6, 8, and 24 hours after administration. The samples were extracted with trichloroacetic acid, followed by colorimetric measurement. The excretion profile showed a curve with concentrations of 14.4, 15.2, 15.6, 14.9, and 14.2% at 2, 4, 6, 8, and 24 hours, respectively. This suggests that 74.3% of ascorbic acid to be excreted via urine as an excessive amount and a high adjuvant dosage should be reconsidered.
Authors and Affiliations
Mutakin Mutakin
Keywords
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