Anaemia in HIV-Positive Patients in Relation to Immune Status of the Disease - A Hospital Based Study
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 1
Abstract
Introduction: Disorders of hematopoietic system including anemia, leucopenia and thrombocytopenia are common throughout the course of HIV infection. Anemia is common in patients with HIV infection, particularly those with advanced disease. Anemia is associated with quality of life decrements, decreased survival and increased disease progression in adults with HIV infection. It has adversely changing patient's quality of life and hamper treatment of both the primary viral infection and the secondary infections. Material and Methods: This is a prospective cross sectional study of 500 HIV positive patients, conducted in the Department of Pathology of Government Medical College and Hospital between the period two years. The hematological parameters were obtained by processing whole blood on Electronic Cell counter. Demographical and clinical data of the patient was also obtained. Data obtained from Electronic counter, peripheral smear examination and BD FACScan flow cytometer was put together and analyzed. Results: Anaemia was the most common haematological abnormality observed. The overall prevalence of anaemia, neutropenia, thrombocytopenia, lymphopenia, leucopenia, pancytopenia and eosinophilia was 70%, 3.4%, 3.4%, 7.6%, 5.6%, 4.0% and 9.8% respectively. The prevalence of anemia and other hematological abnormalities were higher in patients with advanced disease, CD4 count <200/ µl. ART was associated with lower prevalence of anemia Conclusion: Prevalence of haematological abnormalities in HIV positive patients is significantly high even in this HAART era. Anemia is the most common hematological abnormality in HIV seropositive patients and its incidence is strongly associated with the progression of the disease. ART is associated with reduced prevalence of Anaemia and has therapeutic and preventive implications.
Authors and Affiliations
Dr Amitkumar Bapuso Pandav
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