Analgesia for Moderate Chronic Non-Cancer Pain : Low Dose Transdermal Buprenorphine A Novel Option in Mexico
Journal Title: Journal of Anesthesia and Surgery - Year 2016, Vol 3, Issue 1
Abstract
Chronic non-cancer pain is prevalent in Mexico and its pharmacologic treatment requires clinicians to balance the risks and benefits of various analgesic agents NSAIDs and paracetamol acetaminophen can be effective for mild to moderate pain but safety considerations place limitations on their use Opioids are safe and effective but have opioid-associated side effects plus the potential for abuse Against this background it is important to appraise other options with regard to favorable efficacy and safety ndash such aslow-dose transdermal buprenorphine Buprenorphine both in transdermal and oral formulations has been available in Mexico for a number of years yet just recently a Low-Dose Transdermal Patch formulation has been available for the management chronic non-cancer pain of moderate intensity in adults Buprenorphine is an opioid agent with a unique pharmacological profile such that it has a ceiling effect for respiratory depression but no ceiling effect for analgesia It can be used without dose adjustment in the elderly and in patients with impaired kidney function unique among opioids Its small lipophilic molecule makes it well suited to transdermal formulations which offer steadystate round-the-clock analgesia after three days with clinical convenience and easier patient compliance Buprenorphine is an effective analgesic in chronic non-cancer pain patients and its good tolerability and lower abuse potential may make lowdose transdermal buprenorphine appropriate for a broad range of patients
Authors and Affiliations
Joseph V Pergolizzi
Keywords
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- EP ID EP418818
- DOI 10.15436/2377-1364.16.022
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