Analgesic Activity Of Artesunate By Central Mechanism In Experimental Animal - Model
Journal Title: International Journal of Medical and Health Sciences - Year 2012, Vol 1, Issue 3
Abstract
The present study was undertaken to assess the central analgesic effect of Artesunate in Swiss albino mice. The analgesic action in acute pain model was studied by the tail flick method. Thirty six swiss albino mice were divided into three groups of twelve animals (six males and six females) each and maintained under ideal laboratory conditions. Group I was taken as control and group II treated with Pentazocine (50mg/kg intraperitonially) and group III was treated with Artesunate (36.4mg/kg intraperitonially). In the present study, the effect of artesunate alone for its central analgesic activity has been evaluated. It was observed that Artesunate possess a significant (p<0.001) central analgesic activity. The central analgesic activity of Artesunate can be due to rise in the pain threshold and thus increase the capacity to tolerate pain as its activity has been compared with pentazocine.
Authors and Affiliations
Shyamjith Mannikoth, Manohar V. R, Chandra shekar. R, Rao S. N
Keywords
Related Articles
- EP ID EP39668
- DOI -
- Views 274
- Downloads 0
Left Congenital Diaphragmatic Hernia: A Case Report
Congenital diaphragmatic hernia occurs when the diaphragm fails to fuse properly during fetal development, allowing the abdominal organs to move up into the chest cavity. The diagnosis can be made in the prenatal period...
Rare Case of Neck Swelling In An Adult
Cystic lymphangioma is rare congenital malformation commonly seen in children. Its occurrence in adults is uncommon with very scarce reports in the literature. Cysticlymphangioma mainly seen in infants or children youn...
The Roles of G-protein coupled receptors in health and disease conditions
The super family of G-protein-coupled receptors (GPCRs) is the main target for the actions exerted by hormones, drugs and neurotransmitters. Each GPCR shows preferential coupling to some members of the Gprotein family s...
Acute Acalculous Cholecystitis in Enteric fever: A Case Report
Acute acalculous cholecystitis is a very rare complication of typhoid fever, and may be due to multi-drug resistant and virulent forms of Salmonella infection. It is particularly rare in adults. A 27-year-old woman, pr...
Post Natal Growth Pattern of Infants Less than 2,500grams Using Z Scores
Background: Low birth weight has many adverse consequences, some of which might be ameliorated if there is good postnatal compensatory or catch-up growth. Aim of the study: To record growth pattern in Low birth weight i...