Abstract

Objective: To evaluate analgesic property of leaf methanol extract of Cryptostegia grandiflora (Roxb.) R.Br. using mice. Methods: Analgesic activity was evaluated by abdominal writhing and tail flick methods using Swiss albino mice. Acetyl salicylic acid was used as standard drug. Result: The leaf methanol extract did not show any signs of toxicity upto 5000 mg/kg b.w. The leaf methanol extract (LME) was tested at three different dosages viz., 250, 500 and 750 mg/kg b.w. orally. All the three doses of LME showed significant (P<0.001) analgesic activity, among them dose at 750 mg/kg b.w. showed 62.93% inhibition, but less effective than standard acetyl salicylic acid (93.70%) as revealed by writhing test. In Tail-flick model, the LME at the dose of 500 mg/kg b.w. showed significant activity (P<0.001) when compared to the other two doses as evidence by the increase in the latency of tail response to thermal stimulation. Conclusions: This investigation revealed that the C. grandiflora LME demonstrated significant analgesic effect in both abdominal writhing and tail flick models. Among the three different doses tested, the 500 mg/kg b.w. was found to be more potent. The results of this investigation revealed that the LME of C. grandiflora possesses significant analgesic property and supported the traditional medicinal claims on C. grandiflora.

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