Analgesic and Anti-inflammatory Activity of Hydro-alcoholic Extract of Juglans regia
Journal Title: International journal of Emerging Trends in Science and Technology - Year 2017, Vol 4, Issue 9
Abstract
Analgesic and antipyretic effects of hydroalcholic extract of fruits of Juglans regia (Juglandaceae) were investigated at doses 150 mg/kg b.w. and 300mg/kg b.w. using acetic-acid induced writhing, hot- plate, tail-clip, formalin and yeast-induced pyrexia tests. Oral administration Juglans regia hydro-alcholic extract produced significant (P<0.0001) reduction in no. of writhes induced by acetic-acid. Moreover, in hot-plate test, Juglans regia hydro-alcholic extract significantly (P<0.0001) raised the pain threshold at different time of observation (0-60min) in comparison with control. In tail-clip test also the extract caused a significant (P<0.0001) inhibition of pain at both the doses used. There was a significant dosedependent inhibition of both phases of the formalin induced pain response in mice. Tested on yeastinduced pyrexia in rats, Juglans regia hydro-alcholic extract significantly (P<0.0001) reversed hyperthermia at either dose. The results of pharmacological tests performed in the present study suggest that Juglans regia hydro-alcholic extract possesses potent analgesic and antipyretic effects
Authors and Affiliations
Joshi Ankur
Keywords
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