Analgesic and anti-inflammatory activity of stereoisomers of carane derivatives in rodent test.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 6
Abstract
Our previously conducted pharmacological investigations led us to discovery of the strong local anesthetic activity of the compound KP-23RS. The following studies revealed that its R- and S-diasteroisomers had different activity in the local anesthetic, anti-aggregating, anti-arrhythmic and spasmolytic tests. Also the influence of KP-23RS and its diastereoisomers on the cyclic adenosine monophosphate (AMP) generating system was described. In the present study, anti-inflammatory and analgesic effects of these compounds were investigated in hind paw edema test, Randall's analgesia test and hot-plate test. Also the spasmolytic activity and the influence on the stomach mucous membrane were examined. All of these compounds had an anti-inflammatory and analgesic activity in hot-plate test and in Randall's test. Moreover, compound KP-23R showed spasmolytic activity. None of the investigated compounds induced damage of the mucous membrane of the rat stomach.
Authors and Affiliations
Tadeusz Librowski
Keywords
Related Articles
- EP ID EP107360
- DOI -
- Views 108
- Downloads 0
Versatile effects of sildenafil: recent pharmacological applications.
Sildenafil is a phosphodiesterase-5 (PDE5) inhibitor and is predominantly used in the treatment of erectile dysfunction. While maintaining an excellent safety and tolerability profile in the management of erectile dysfun...
Cannabinoid CB1 receptors in rat medial prefrontal cortex are colocalized with calbindin- but not parvalbumin- and calretinin-positive GABA-ergic neurons.
In the present study, we investigate putative localization of cannabinoid receptors 1 (CB1) protein on a population of cortical gamma-aminobutyric acid (GABA) - positive interneurons characterized by expression of calciu...
Vane's discovery of the mechanism of action of aspirin changed our understanding of its clinical pharmacology.
Aspirin exerts its analgesic, antipyretic and anti-inflammatory actions by inhibiting the enzyme cyclooxygenase and thus preventing the formation and release of prostaglandins. The elucidation by John Vane of the mechani...
Abstracts of the Third Conference on PROGRESS IN EPILEPTIC AND ANTIEPILETIC DRUGS.
Single centre 20 year survey of antiepileptic drug-induced hypersensitivity reactions.
Background: Epilepsy is a chronic neurological disease which affects about 1% of the human population. There are 50 million patients in the world suffering from this disease and 2 million new cases per year are observed....