Analgesic and Anti-Inflammatory Studies on The Roots Argemone Mexicana Linn(FAMILY: PAPAVERACEAE)
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 3
Abstract
Analgesic and anti inflammatory studies of the ethanol extract of the roots of A. mexicana were studied in mice and rats respectively. Acetic acid-induced writhing in mice and hind paw oedema in rats were determined. The results of these studies showed the extract to possess anti-nociceptive activity which is dosedependent at 50mg and 100mg/kg (i.p) in mice and in the same way a slight inflammatory activity at 50 and 100mg/kg were observed. The extract was also found to have an intraperitoneal (i.p) LD50 of 368.00mg in mice. These results correlate with the traditional use of the plant by the traditional medical healers and support the use of the plant in the management of inflammation and skin diseases.
Authors and Affiliations
H. A. Ibrahim*, Mahmud Ali Umar, cBilkisu A Bello, Abdulazeez Aliyu
Keywords
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- EP ID EP384979
- DOI 10.9790/3008-1103049295
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