Analgesic, anti-inflmmatory and antipyretic activities of methanolic leaf extract of Maerua crassifolia
Journal Title: Journal of Coastal Life Medicine - Year 2016, Vol 4, Issue 3
Abstract
Objective: To investigate the the analgesic, anti-inflammatory and antipyretic activities of the methanolic leaf extract of Maerua crassifolia in mice and rats. Methods: Acetic acid-induced writhing and tail immersion methods were used to assess analgesic activity, while xylene and carrageenan-induced paw oedema methods were used to evaluate the anti-inflammatory effect of the leaf extract. Yeast and amphetamine-induced pyrexia were used to investigate the antipyretic activity. The phytochemical analysis and oral acute toxicity of the methanolic leaf extract of Maerua crassifolia were also evaluated. Results: The leaf extract (100, 200, and 400 mg/kg) showed a dose dependent and significant (P < 0.05) inhibition of pain in acetic acid-induced writhing and tail immersion tests. The extract also produced significant (P < 0.05) anti-inflammatory activity in both paradigms. A significant (P < 0.05) reduction in hyperpyrexia was also observed with the leaf extract. The phytochemical screening revealed the presence of alkaloids, flavonoids, terpenoids, tannins, steroids, resins, saponins and cardiac glycosides. The oral median lethal dose of the leaf extract was estimated to be greater than 5 000 mg/kg in rats. Conclusions: The findings confirmed its ethnomedical use in the treatment of pains and feverish conditions.
In vitro bioactivity and phytochemical analysis of two marine macro-algae
Objective: To evaluate the in vitro bioactivity and phytochemical analysis of two marine macro-algae viz., Sargassum wightii (S. wightii) and Gracilaria verrucosa (G. verrucosa). Methods: The marine macro-algae were coll...
An update of therapeutic potential and bioanalytical aspects of steroidal glycoalkaloid (solanidine)
Alkaloids are one of the main secondary metabolite of original plants and known for their beneficial health aspects. Chemically alkaloids are basic compounds and found in various parts of plants like fruits, flowers, see...
Aquagenic urticaria due to sea water contact
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Evaluation of metallothionein content in giant mudskipper Periophthalmodon schlosseri collected from west coast of Peninsular Malaysia to assess environmental metal pollution
Objective: To evaluate the concentrations of metallothionein (MT) in giant mudskippers Periophthalmodon schlosseri (P. schlosseri) and to elucidate their potential use in bio monitoring of coastal environment. Methods: T...
Thermotolerant coliform counts and nutrient levels as indicators of water quality in sub-Mediterranean karst river
Objective: To evaluate temporal and spatial nutrient level regimes and thermotolerant coliform counts (TTC) as water quality determinants. Methods: The annual research was conducted from November 2014 to November 2015, o...