Analgesic, anti-inflmmatory and antipyretic activities of methanolic leaf extract of Maerua crassifolia
Journal Title: Journal of Coastal Life Medicine - Year 2016, Vol 4, Issue 3
Abstract
Objective: To investigate the the analgesic, anti-inflammatory and antipyretic activities of the methanolic leaf extract of Maerua crassifolia in mice and rats. Methods: Acetic acid-induced writhing and tail immersion methods were used to assess analgesic activity, while xylene and carrageenan-induced paw oedema methods were used to evaluate the anti-inflammatory effect of the leaf extract. Yeast and amphetamine-induced pyrexia were used to investigate the antipyretic activity. The phytochemical analysis and oral acute toxicity of the methanolic leaf extract of Maerua crassifolia were also evaluated. Results: The leaf extract (100, 200, and 400 mg/kg) showed a dose dependent and significant (P < 0.05) inhibition of pain in acetic acid-induced writhing and tail immersion tests. The extract also produced significant (P < 0.05) anti-inflammatory activity in both paradigms. A significant (P < 0.05) reduction in hyperpyrexia was also observed with the leaf extract. The phytochemical screening revealed the presence of alkaloids, flavonoids, terpenoids, tannins, steroids, resins, saponins and cardiac glycosides. The oral median lethal dose of the leaf extract was estimated to be greater than 5 000 mg/kg in rats. Conclusions: The findings confirmed its ethnomedical use in the treatment of pains and feverish conditions.
Comparative study of hypoglycemic and antibacterial activity of organic extracts of four Bangladeshi plants
Objective: To examine hypoglycemic and antibacterial activity against some Gram-positive and Gram-negative bacteria of organic extracts of four Bangladeshi plants. Methods: An in vivo hypoglycemic effect on mice model wa...
Anti-inflmmatory, analgesic and antipyretic potentials of marine sponge Sigmadocia pumila
Objective: To study the pharmacological properties of Sigmadocia pumila (S. pumila), a marine sponge, through in-vivo analysis. Methods: The anti-inflammatory activity was determined by the carrageenan-induced rat paw ed...
Correlation study of some physico-chemical parameters and benthic macroinvertebrates metrics on the ecological impacts of flriculture industries along Wedecha River, Debrezeit, Ethiopia
Objective: To assess the quality of water using biological and chemical information correlation study. Methods: A total of 6 sites, one reference site less impaired to represent natural conditions from upstream, and 5 im...
Bee sting keratopathy with retained stinger
This case report aims to report an uncommon case of bee sting keratopathy with retained stinger. A 55-year-old man presented with left cornea bee sting while gardening two days prior to first visit. He complained of seve...
Variability in patterns of macro-epiphytic leaf community of Posidonia oceanica in the Islands of Kuriate: Western coast of Tunisia
Objective: To test the response of the epiphyte community structure and biomass of the Posidonia oceanica (P. oceanica) leaves to natural disturbance. Methods: Sampling of P. oceanica was carried in winter and summer on...