Analgesic effect of methanolic extract of Vetiveria zizanoides in wistar rats
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2014, Vol 2, Issue 2
Abstract
Introduction: Vetiveria zizanoides is used as a traditional medicine for a number of conditions, but there is lack of scientific data regarding its analgesic action.Aim: to study the analgesic action of methanolic extract of Vetiveria zizanoides (VZ) on animal models of analgesiaMethods: The animals were divided in to four groups (n=6). The groups received gum acacia, tramadol, VZ 300mg/kg and VZ 500 mg/kg orally. The analgesic effect of the plant extract was tested using hot plate and tail flick models.Results: VZ500 mg/kg produced a significant analgesic action in both the models of analgesia which was comparable to that of tramadol. VZ 300mg/kg produced significant analgesic action only hot plate model.Conclusion: The present study suggests the central analgesic action of methanolic extract of Vetiveria zizanoides. Further studies are required to confirm its analgesic action
Authors and Affiliations
Bharti Chogtu Magazine| Department of Pharmacology, Kasturba Medical College, Manipal, Manipal University, Karnataka, India, Veena Nayak*| Department of Pharmacology, Kasturba Medical College, Manipal, Manipal University, Karnataka, India, Pradeep AN| Department of Pharmacology, Kasturba Medical College, Manipal, Manipal University, Karnataka, India
Keywords
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