Analysing the Utility of Fresh Frozen Plasma in Neonatal Intensive Care Unit in a Rural Tertiary Care Hospital, South India
Journal Title: Saudi Journal of Pathology and Microbiology - Year 2018, Vol 3, Issue 8
Abstract
Abstract:Transfusion of Fresh frozen plasma is relatively common in neonatal intensive care units. Most common indications for transfusion being neonatal sepsis, deranged coagulation profile or co existence of both these conditions. However a universal protocol for FFP transfusion in neonates is lacking, leading to injudicious administration of FFP to neonates in many hospitals and thus exposing them to untoward risks of transfusion. This is our attempt towards analyzing the use of FFP in our neonatal intensive care unit and our compliance with the established guidelines (AIIMS protocol for FFP transfusion in neonates). Data was collected retrospectively of all the neonates who received FFP transfusions in our hospital from January 2014 to December 2017 and relevant analysis was performed. Most of the neonatal transfusions (93%) at our hospital during the study period were compliant with AIIMS guidelines. Most common indication for transfusion was bleeding manifestations followed by sepsis and deranged coagulation profile. However on analysis of pre and post transfusion coagulation parameters in these babies, no statistically significant improvement was seen.FFP was often used in accordance with the published guidelines in our study. However evidence based uniform guidelines need to be established and implemented to increase the benefit and minimise the risk associated with transfusion, especially in newborns. Keywords: Fresh frozen plasma, transfusion, neonate, sepsis, coagulation.
Authors and Affiliations
Indrani Krishnappa, Uma Bai K R, Rubi na
Keywords
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