ANALYSIS OF BIOACTIVE CONSTITUENTS FROM A NEW STREPTOMYCES VARIABILIS STRAIN SU5 BY GAS CHROMATOGRAPHY - MASS SPECTROMETRY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 11
Abstract
Objectives: To analyze the bioactive constituents found in the crude extract of a new Streptomyces variabilis strain SU5 by gas chromatography - mass spectrometry.Methods: A total of fifty two actinomycetes were isolated from sediment samples of South east coast of Tamil Nadu by the serial dilution method. A new strain was identified based on cultural and molecular analysis as Streptomyces variabilis strain SU 5 and submitted in GENBANK with the accession number KF551876. The ethyl acetate extract of the new strain was produced by submerged fermentation and has been subjected to GC-MS analysis.Results: The major chemical constituents are Diisobutyl phthalate (31.84), Monoethylhexyl phthalate (20.33), tributylamine (13.24), Dibutyl phthalate (5.51), 2-Bromotetradecane (3.79) with the retention time 15.635, 21.606, 7.164, 16.608, 12.657 respectively.Conclusion: The presence of some of these constituents in the actinomycetes extract provides the scientific evidences for eliminating tumor cells in bone marrow, purging agent in autologous bone marrow transplantation, cytotoxic activity, stimulates adipogenesis and glyceroneogenesis, affects the differentiation of Human Liposarcoma.Â
Authors and Affiliations
Sudha Sri Kesavan, M. Bavanilatha, R. Vijyalakshmi, S. Hemalatha
Keywords
Related Articles
- EP ID EP579294
- DOI -
- Views 43
- Downloads 0
CHEMICAL CHARACTERISATION OF ALPINIA GALANGA (L.) WILLD BY GC–MS, XRD, FTIR AND UV-VIS SPECTROSCOPIC METHODS
Objective: Present study was aimed to produce the chemical profile of Alpinia galanga (L.) Willd by various analytical methods.Methods: The sample extracted with methanol were screened for their volatile organic constitu...
ANTIMICROBIAL RESISTANCE OF PSEUDOMONAS AERUGINOSA STRAINS FROM PATIENTS WITH URINARY TRACT INFECTIONS IN SBMPMC HOSPITAL BIJAPUR, INDIA
Objectives: Urinary tract infections (UTIs) are one of the most common bacterial infections affecting humans throughout their life span. There is paucity of literature in relation to pathogenesis of UTIs caused by Pseudo...
STUDY OF ARACHIDONIC ACID RELEASING STATUS IN DIABETIC RATS TREATED WITH FLAXSEED OIL
Objective: Diabetes mellitus increased inflammation through stimulation of arachidonic acid liberation from the cell membranes which is transformed into actively cellular mediators such as thromboxanes, prostaglandins, a...
A REVIEW: MECHANISTIC INSIGHTS INTO THE EFFECT OF THYROID DISORDERS ON ESTROGEN LEVEL AND BONE MINERAL DENSITY
Thyroid hormone serves as an indispensable component for the optimum functioning of various biological systems. They curb body’s metabolism, regulates the estrogen level, regulates bone turnover, essential for skeletal d...
TRANSDERMAL PATCHES OF CHITOSAN NANOPARTICLES FOR INSULIN DELIVERY
Objectives: To develop a nanoparticle system with Chitosan for transdermal delivery of insulin.Methods: Chitosan and Tripolyphosphate (TPP) were used to prepare the insulin loaded chitosan nanoparticles based on ionotrop...