Analysis of capecitabine plus oxaliplatin (xelox) combination in the management of metastatic colorectal cancer compare with fluorouracil and oxaliplatin combination (folfox)
Journal Title: Jurnal Kedokteran dan Kesehatan Indonesia - Year 2016, Vol 7, Issue 5
Abstract
Background : Combinations of Fluorouracil (FU) and biomodulator Leucovorin (LV) established as a standard regimen for therapy of colorectal cancer with metastases. To give better antitumor activity in colorectal cancer therapy, oxaliplatin is combined with FU/LV and give significant improvement. Fluorouracil can only be given by intravenous administration. This limitation raised effort to find alternative drugs that can be given orally, such as capecitabine. Capecitabine is an oral FU prodrug, with high oral bioavailability, highly accumulated in neoplastic tissue to be converted in FU, and well tolerated. Some clinical studies revealed effectivity of capecitabine plus oxaliplatin (XELOX) compared to FU/LV plus oxaliplatin (FOLFOX). Objective : This article is aimed to compare non inferiority of XELOX to FOLFOX in colorectal cancer with metastases, viewed form primary outcomes and secondary outcomes. Results : XELOX was comparable to FOLFOX with some benefitsover FOLFOX. Conclusion : XELOX could be considered as FOLFOX replacement as a standard therapyfor colorectal cancer with metastases.
Authors and Affiliations
Isnatin Miladiyah
Keywords
Related Articles
- EP ID EP253702
- DOI 10.20885/JKKI.Vol7.Iss5.art4
- Views 98
- Downloads 0
Pharmacovigilance of herbal medicine in two public health centers of Yogyakarta
Background : The use of herbal medicine in Indonesia is getting increase. People try to keep their health or to prevent some diseases using herbal medicines. However, the safety of herbal medicine used in community has n...
Interactive e-learning in pharmacology to enhance student competency in faculty of medicine UII
Background : E-learning provides an opportunity for students to improve their knowledge by promoting self-directed learning. The aim of this e-learning is to encourage pharmacology active learning among undergraduate stu...
Wild Boar Fat Analysis in Beef Sausage Using FTIR Method (Fourier Transform Infrared) Combined with Chemometrics
Background: Sausage is ready to eat meals for children, adolescents, and older adults. The meat contained in a beef sausage might not be consistent to the one listed on the label. Fourier Transform Infrared (FTIR) spect...
The effect of the onset of seizure on clock drawing test score of epilepsy patients
Background: Epilepsy is one of the causing factors of cognitive impairment which affects the patient’s quality of life. The most critical risk factor for cognitive impairment in epilepsy patients is the onset of seizure....
The cytotoxic effect of pinostrobin fingerroot (boesenbergia pandurata)on the culture of hela cells
Background : Cancer is one of the leading causes of death worldwide, therefore struggles to find more effective treatment and prevention is needed. Several studies has been performed using natural ingredients, one of whi...