Analysis of Cathinone and Cathine in Urine Sample of Khat Chewer Presenting with Hemorrhagic Stroke
Journal Title: Journal of Gynecology and Neonatal Biology - Year 2018, Vol 3, Issue 1
Abstract
Khat contains cathinone and cathine, which are known to be associated with myocardial infarction and cerebral hemorrhage. Thereis limited data showing a relationship between khat chewing and hemorrhagic stroke. In Jazan region, the most of stimulant toxicity cases were toxicated by both khat and amphetamine. This report represents a khat chewer whose toxicity was only suspected to be from khat chewing. Thelevels of cathine and cathinone in the blood and urine samples of a khat chewer were determined. The method of extraction and analysis were discussed. The results of initial analysis were negative for amphetamine, cocaine, opiate, barbiturate and tricycle antidepressant. The urine initial analysis results were positively for amphetamine like substance. On further investigation, the confirmatory analysis by liquid chromatography-tandem mass spectrometry LC-MS/MS in urine were detected and quantified cathine and cathinone.
Authors and Affiliations
Attafi M. I
Keywords
Related Articles
- EP ID EP428929
- DOI 10.15436/2575-808X/18.1868
- Views 95
- Downloads 0
Cellular Responses in Titanium Dioxide Nanoparticle Cytotoxicity Studies: Parts of the Map Waiting to be Composed
With the infiltration of nanotechnology into our daily life, exposure to Titanium Dioxide Nanoparticles (TNPs) has become inevitable. Many forms of exposures are capable of affecting the human health. Current research in...
Analysis of Cathinone and Cathine in Urine Sample of Khat Chewer Presenting with Hemorrhagic Stroke
Khat contains cathinone and cathine, which are known to be associated with myocardial infarction and cerebral hemorrhage. Thereis limited data showing a relationship between khat chewing and hemorrhagic stroke. In Jazan...
Antibacterial Activities of Nanoparticles of Titanium Dioxide, Intrinsic and Doped with Indium and Iron
The need for new antimicrobial compounds has been attention on developing new and emerging materials based on nanoparticles with antimicrobial activity. The aim of this research was to evaluate the antibacterial activiti...
The Role of Lycopene as Antioxidant and Anti-inflammatory in Protection of Oxidative Stress Induced by Metalaxyl
Pesticides play an important role in hepatotoxicity and liver damage. Lycopene is known to possess several beneficial properties including; antioxidant and anti-cancer effects. However, there is a lack of relevant inform...
QSAR Modeling useful in Anti-Cancer Drug Discovery: Prediction of V600EBRAF-Dependent P-ERK using Monte Carlo Method
Quantitative structure−activity relationship (QSAR) modeling is one of the major computer aided modeling employed in medicinal chemistry. It is used for developing relationships between the effects (e.g. activities and p...