Analysis of Cathinone and Cathine in Urine Sample of Khat Chewer Presenting with Hemorrhagic Stroke
Journal Title: Journal of Gynecology and Neonatal Biology - Year 2018, Vol 3, Issue 1
Abstract
Khat contains cathinone and cathine, which are known to be associated with myocardial infarction and cerebral hemorrhage. Thereis limited data showing a relationship between khat chewing and hemorrhagic stroke. In Jazan region, the most of stimulant toxicity cases were toxicated by both khat and amphetamine. This report represents a khat chewer whose toxicity was only suspected to be from khat chewing. Thelevels of cathine and cathinone in the blood and urine samples of a khat chewer were determined. The method of extraction and analysis were discussed. The results of initial analysis were negative for amphetamine, cocaine, opiate, barbiturate and tricycle antidepressant. The urine initial analysis results were positively for amphetamine like substance. On further investigation, the confirmatory analysis by liquid chromatography-tandem mass spectrometry LC-MS/MS in urine were detected and quantified cathine and cathinone.
Authors and Affiliations
Attafi M. I
Keywords
Related Articles
- EP ID EP428929
- DOI 10.15436/2575-808X/18.1868
- Views 71
- Downloads 0
Antimicrobial Activity Studies from Poisonous Short Nosed Tripod Fish, Triacanthus biaculeatus (Bloch, 1786) from Visakhapatnam Coastal Waters, India
An antimicrobial validatory screening of short nosed tripod fish Triacanthus biaculeatus (Bloch, 1786) collected from the Visakhapatnam coastal waters, India is done in such a way T. biaculeatus muscle extracts were subj...
Antibacterial Activities of Nanoparticles of Titanium Dioxide, Intrinsic and Doped with Indium and Iron
The need for new antimicrobial compounds has been attention on developing new and emerging materials based on nanoparticles with antimicrobial activity. The aim of this research was to evaluate the antibacterial activiti...
Effect of Steroidal Saponins-Loaded Composite Scaffolds on Bone Healing
The objective of this study was to investigate the therapeutic potential of nano- bioglass/phosphatidylserine/collagen scaffolds loaded with steroidal saponins as an inducer factor for skeletal defects. The drugs-encapsu...
Design, Modeling, Synthesis and in Vitro Evaluation of New DPP-IV Inhibitors
Dipeptidyl peptidase-IV enzyme is one of the targets for drug design to compact type-2 diabetes. The current research addresses the design, modeling, synthesis and in vitro testing of potential new DPP-IV inhibitors. X-r...
The Role of Lycopene as Antioxidant and Anti-inflammatory in Protection of Oxidative Stress Induced by Metalaxyl
Pesticides play an important role in hepatotoxicity and liver damage. Lycopene is known to possess several beneficial properties including; antioxidant and anti-cancer effects. However, there is a lack of relevant inform...