Analysis of causation of Stevens Johnson Syndrome in a patient of rheumatoid arthritis with increased dose of methotrexate
Journal Title: International Archives of Integrated Medicine - Year 2017, Vol 4, Issue 12
Abstract
Rheumatoid arthritis (RA) is an autoimmune disease affecting about 1% of people, with the highest incidence between 40 and 70 years. Methotrexate is a folic acid antagonist that has good efficacy and safety in the treatment of RA. Methotrexate (MTX) and non-steroidal anti-inflammatory drugs are often concomitantly administered in clinical practice for the treatment of RA. In this case report 46 year old male patient, a known case of rheumatoid arthritis was admitted with history of knee joint pain and swelling. Methotrexate was initially started in a dose of 7.5 mg per week, dose was then increased to 15 mg per week. Six weeks later, the patient complained of oral ulcerations, erythematous, itchy and edematous rash on all four limbs and trunk. The patient was re-evaluated and was diagnosed with Stevens-Johnson syndrome. All the previous medications were stopped. The patient was treated with steroids, prophylactic antibiotics and antifungal drugs. The lesions started to heal after 5 days of hospitalization. Thus the treatment of Rheumatoid arthritis with methotrexate should be carefully considered due to its increased toxicity and risk of severe skin reactions.
Authors and Affiliations
Manab Nandy, Sangeeta De, Mustafa Asad, Nirmal Polle
Keywords
Related Articles
- EP ID EP412959
- DOI -
- Views 126
- Downloads 0
Radiological assessment of age of adolescents from wrist joint: A prospective study of 151 cases
It is a prospective, radiological study of age assessment of 151 cases of young adolescents (Boy = 70; Girl = 81) in the age range of 14-17 years by taking A-P view X-rays of their right wrist including hands. This study...
Quality of life assessment after modified radical mastectomy in early breast cancer
Background: Modified radical mastectomy performed for CA breast is a life modifying surgery for most women. It creates a profound impact on the quality of life enjoyed by the women. The magnitude of change in quality may...
Maternal and Perinatal Outcome in Twin Gestation in a Referral Hospital at Visakhapatnam
Background: Multiple births have been a subject of great interest to various Scientists such as endocrinologists and geneticists, a source of fascination to some people and a causes concern to obstetrician and pediatrici...
A study on perceptions about eye health care and promoting factors for eye donation among medical students from a tertiary care teaching hospital
Background: Voluntary eye donation depends on the awareness levels of various stakeholders in the community. Today’s medical students are tomorrow’s stakeholders of the community. Medical professionals can enhance eye do...
Ovarian tumors - Incidence and histopathological spectrum in tertiary care center, Valsad
Introduction: Ovarian tumors are now the one of the leading cause of death involving a wide spectrum of clinical, morphological and histopathological diagnosis. It frequently does not result in symptoms until the tumor h...