Analysis of clinical relevance of chrono pharmacology in therapy of respiratory disorders in a tertiary care hospital- A prospective observational study
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2017, Vol 4, Issue 4
Abstract
Introduction: Drugs following administration itself affect the biological rhythm or biological rhythm can affect the drug action. Administration of drugs according to biological rhythm helps in optimization and quantification of the drug effects and thereby aids in potentiation of desired effects while minimizing the undesired effects. Objectives: To study the chronopharmacological relevance to time of drug administration in respiratory disorders in Medicine in-patients at a tertiary care hospital. Methodology: A prospective non- interventional observational study was conducted on Medicine inpatients of a tertiary care hospital to study the relevance of chronopharmacology in respiratory disorders. Patients were included in the study based on inclusion and exclusion criteria. Data was recorded on a predesigned proforma. Results: Theophylline, montelukast, levocetrizine, chlorpheniramine have been administered appropriately at bedtime and prednisolone accordingly in the morning in all the subjects thereby showing 100% relevance. However etophylline was administered according to chronopharmacology in 71% of subjects only. Conclusion: Most of the drugs recorded in the study were administered according to their relevance to circadian rhythm, while only a few drugs are lagging in the trend which needs to be addressed.
Authors and Affiliations
Dharani Devangi, Shashirekha C. H, Shruthi S L
Keywords
Related Articles
- EP ID EP295786
- DOI 10.18231/2393-9087.2017.0039
- Views 92
- Downloads 0
Phytochemical analysis and Antimicrobial activity of HAGENIA ABYSSINICA
Introduction: Ethiopian communities highly depend on local plants to safe and sound their survival and health. Local trees are subjugated and used intensively for medicinal uses. Objective: The aim of the present study w...
A Cross-Sectional study of Drug Prescription Pattern in Urticaria patients attending Dermatology & Venereology Department in a Rural Tertiary Care Teaching Hospital
Background: Urticaria is a very common skin condition characterized by recurrent, pruritic (itchy), pink-to-red edematous (swollen) lesions that often have pale centers (wheals). Histamine is the main mediator of urticar...
Development and Validation of RP-HPLC Method for Simultaneous Estimation of Paracetamol and Tramadol Hydrochloride
A simple and rapid RP-HPLC method has been developed for the simultaneous estimation of paracetamol and tramadol hydrochloride. The chromatographic analysis was carried out on an Enable C18 column (250×4.6 mm i.d., 5µm)...
Pattern of availability of non-prescribed medicines and their use as self-medication in Gujarat: a house hold survey
Selfmedication is widely practiced everywhere in the world The drug for self medication has proven efficacy and safety for shortterm use in minor illnesses but there is the potential for misuse and abuse of themA cross s...
Adverse drug reactions due to immunosuppressants reported in renal transplant recipients in a tertiary care hospital
Introduction Tacrolimus mycophenolate sodium and prednisolone are used in combination as maintenance treatment in patients who have undergone kidney transplantation These drugs are used to prevent acute graft rejectionAi...